Pyruvate Dehydrogenase (Lipoamide) alpha 1 抗体
(Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1))
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010].
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Latest Publications for our Pyruvate Dehydrogenase (Lipoamide) alpha 1 抗体
: "The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer." in: Cancer & metabolism, Vol. 7, pp. 1, (2019) (PubMed).: "Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions." in: Cell reports, Vol. 22, Issue 6, pp. 1509-1521, (2019) (PubMed).
: "ORP4L Extracts and Presents PIP2 from Plasma Membrane for PLCβ3 Catalysis: Targeting It Eradicates Leukemia Stem Cells." in: Cell reports, Vol. 26, Issue 8, pp. 2166-2177.e9, (2019) (PubMed).
: "Loss of GCN5L1 in cardiac cells limits mitochondrial respiratory capacity under hyperglycemic conditions." in: Physiological reports, Vol. 7, Issue 8, pp. e14054, (2019) (PubMed).
: "The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA." in: The Journal of biological chemistry, Vol. 293, Issue 46, pp. 17676-17684, (2018) (PubMed).
: "Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids." in: Gut, (2018) (PubMed).
: "The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle." in: JCI insight, Vol. 3, Issue 22, (2018) (PubMed).
: "MicroRNA-23a promotes colorectal cancer cell survival by targeting PDK4." in: Experimental cell research, Vol. 373, Issue 1-2, pp. 171-179, (2018) (PubMed).
: "MiR-494-3p regulates mitochondrial biogenesis and thermogenesis through PGC1-α signalling in beige adipocytes." in: Scientific reports, Vol. 8, Issue 1, pp. 15096, (2018) (PubMed).
: "Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics." in: Biochimica et biophysica acta, Vol. 1864, Issue 6, pp. 1009-1017, (2017) (PubMed).
Aliases for Pyruvate Dehydrogenase (Lipoamide) alpha 1 抗体
pyruvate dehydrogenase E1 alpha 1 subunit (PDHA1) 抗体pyruvate dehydrogenase E1 alpha 1 (Pdha1) 抗体
pyruvate dehydrogenase E1 alpha 1 subunit (Pdha1) 抗体
pyruvate dehydrogenase (lipoamide) alpha 1 (PDHA1) 抗体
pyruvate dehydrogenase E1 alpha 1 subunit (pdha1) 抗体
pyruvate dehydrogenase (lipoamide) alpha 1 pseudogene (LOC719277) 抗体
2-oxo acid dehydrogenase (VNG_RS07485) 抗体
pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha (RR_RS04695) 抗体
pyruvate dehydrogenase alpha subunit protein (pdhA1) 抗体
pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit (pdhA1) 抗体
precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit (PDHA1) 抗体
pyruvate dehydrogenase (PDHA1) 抗体
pyruvate dehydrogenase E1 alpha 1 subunit a (pdha1a) 抗体
pyruvate dehydrogenase E1 alpha 1 subunit b (pdha1b) 抗体
pyruvate dehydrogenase E1 component subunit alpha (NI36_RS05240) 抗体
pyruvate dehydrogenase (lipoamide) alpha 1 S homeolog (pdha1.S) 抗体
im:6895726 抗体
NI36_05250 抗体
PDHA 抗体
pdha 抗体
Pdha-1 抗体
pdha1 抗体
Pdha1 抗体
pdha1-a 抗体
pdha1-b 抗体
PDHCE1A 抗体
pdhce1a 抗体
PHE1A 抗体
phe1a 抗体
wu:fd18b01 抗体
wu:fo96f03 抗体
wu:fp73b04 抗体
zgc:73271 抗体
zgc:86692 抗体
zgc:92705 抗体
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