PTPN7 产品
(Protein tyrosine Phosphatase, Non-Receptor Type 7 (PTPN7))
Categories
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010].
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Featured PTPN7 Categories
Recommended PTPN7 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Dog, Human, Mouse, Rat
Application
WB, IF
Validations
- (3)
Cat. No.
ABIN1500502
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC, ELISA
Validations
- (2)
Cat. No.
ABIN7174120
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (2)
Cat. No.
ABIN519511
Quantity
100 μL
Datasheet
Datasheet
Recommended PTPN7 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6228859
Quantity
96 tests
Datasheet
Datasheet
Recommended PTPN7 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124682
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316855
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316853
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PTPN7 Products
: "Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases." in: The Biochemical journal, Vol. 395, Issue 3, pp. 483-91, (2006) (PubMed).: "Structure of the hematopoietic tyrosine phosphatase (HePTP) catalytic domain: structure of a KIM phosphatase with phosphate bound at the active site." in: Journal of molecular biology, Vol. 354, Issue 1, pp. 150-63, (2005) (PubMed).
: "Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: dynamics and subcellular location." in: The Biochemical journal, Vol. 378, Issue Pt 2, pp. 335-42, (2004) (PubMed).
: "The protein tyrosine phosphatase HePTP regulates nuclear translocation of ERK2 and can modulate megakaryocytic differentiation of K562 cells." in: Leukemia, Vol. 17, Issue 2, pp. 366-78, (2003) (PubMed).
: "Grouping of multiple-lentigines/LEOPARD and Noonan syndromes on the PTPN11 gene." in: American journal of human genetics, Vol. 71, Issue 2, pp. 389-94, (2002) (PubMed).
: "Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome." in: Nature genetics, Vol. 29, Issue 4, pp. 465-8, (2001) (PubMed).
: "Subcellular localization of intracellular protein tyrosine phosphatases in T cells." in: European journal of immunology, Vol. 30, Issue 8, pp. 2412-21, (2000) (PubMed).
Synonyms and alternative names related to PTPN7
protein tyrosine phosphatase, non-receptor type 7 (PTPN7), protein tyrosine phosphatase, non-receptor type 7 (Ptpn7), BPTP-4, C920001D21Rik, HEPTP, Heptp, LC-PTP, Lcptp, LPTP, PTPNIProtein level used designations for PTPN7
- dual specificity phosphatase 1
- hematopoietic protein-tyrosine phosphatase
- protein-tyrosine phosphatase LC-PTP
- protein-tyrosine phosphatase, nonreceptor-type, stress induced
- tyrosine-protein phosphatase non-receptor type 7
- protein-tyrosine phosphatase, non-receptor type 7
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