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PTPN22 产品

(Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22))

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This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009].

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Featured PTPN22 Categories

PTPN22 抗体

High quality antibodies with extensive validation data.

PTPN22 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PTPN22 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC, IF, FACS
Validations
  • (5)
Cat. No. ABIN6391380
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (5)
Cat. No. ABIN1513449
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, RNAi
Validations
  • (4)
Cat. No. ABIN565235
Quantity 100 μg
Datasheet Datasheet

Recommended PTPN22 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6971027
Quantity 96 tests
Datasheet Datasheet

Recommended PTPN22 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1316837
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1316839
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7422139
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our PTPN22 Products

Bayley, Yang, Buckley, Young: "Measuring the specific activity of the protein tyrosine phosphatase Lyp." in: Journal of immunological methods, Vol. 388, Issue 1-2, pp. 33-9, (2013) (PubMed).

Cao, Yang, Colby, Hogan, Hu, Jennette, Berg, Zhang, Jennette, Falk, Preston: "High basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitis." in: PLoS ONE, Vol. 7, Issue 8, pp. e42783, (2012) (PubMed).

Synonyms and alternative names related to PTPN22

protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (Ptpn22), protein tyrosine phosphatase, non-receptor type 22 (PTPN22), protein tyrosine phosphatase, non-receptor type 22 (Ptpn22), 70zpep, LYP, LYP1, LYP2, PEP, Ptpn8, PTPN8

Protein level used designations for PTPN22

  • PEST domain-enriched tyrosine phosphatase
  • hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
  • protein tyrosine phosphatase, non-receptor type 8
  • tyrosine-protein phosphatase non-receptor type 22
  • PEST-domain phosphatase
  • lymphoid phosphatase
  • lymphoid-specific protein tyrosine phosphatase
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