PTPN2 产品
(Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2))
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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011].
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Featured PTPN2 Categories
PTPN2 抗体
High quality antibodies with extensive validation data.
PTPN2 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
PTPN2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PTPN2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (8)
Cat. No.
ABIN3022585
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (3)
Cat. No.
ABIN7444958
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IP
Validations
- (3)
Cat. No.
ABIN519504
Quantity
100 μL
Datasheet
Datasheet
Recommended PTPN2 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4884735
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6386214
Quantity
96 tests
Datasheet
Datasheet
Recommended PTPN2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316834
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Baculovirus infected Insect Cells
Validations
- (1)
Cat. No.
ABIN7197593
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7419406
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PTPN2 Products
: "Protein Tyrosine Phosphatase Nonreceptor Type 2 (PTPN2), an Important Regulator of IL-6 Production in Rheumatoid Arthritis Synovial Fibroblasts." in: Arthritis & rheumatology (Hoboken, N.J.), (2015) (PubMed).: "Reactive oxygen species-responsive miR-210 regulates proliferation and migration of adipose-derived stem cells via PTPN2." in: Cell death & disease, Vol. 4, pp. e588, (2013) (PubMed).
: "T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease." in: Immunological reviews, Vol. 228, Issue 1, pp. 325-41, (2009) (PubMed).
: "TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-{gamma}." in: Blood, Vol. 109, Issue 10, pp. 4220-8, (2007) (PubMed).
: "Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP." in: Molecular and cellular biology, Vol. 23, Issue 6, pp. 2096-108, (2003) (PubMed).
: "Gr-1+ myeloid cells lacking T cell protein tyrosine phosphatase inhibit lymphocyte proliferation by an IFN-gamma- and nitric oxide-dependent mechanism." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 2, pp. 726-32, (2003) (PubMed).
: "Identification of a nuclear Stat1 protein tyrosine phosphatase." in: Molecular and cellular biology, Vol. 22, Issue 16, pp. 5662-8, (2002) (PubMed).
Synonyms and alternative names related to PTPN2
protein tyrosine phosphatase, non-receptor type 2 (PTPN2), protein tyrosine phosphatase, non-receptor type 2 (Ptpn2), protein tyrosine phosphatase, non-receptor type 2 S homeolog (ptpn2.S), protein tyrosine phosphatase, non-receptor type 2, b (ptpn2b), protein tyrosine phosphatase, non-receptor type 2, a (ptpn2a), protein tyrosine phosphatase, non-receptor type 2 L homeolog (ptpn2.L), AI325124, cb806, hm:zeh1546, PTN2, ptn2, PTP-1B, ptpn2, ptpn2l, PTPT, Ptpt, ptpt, TC-PTP, tc-ptp, TCELLPTP, tcellptp, TCPTP, tcptp, wu:fc10h07, zgc:55339, zgc:63623, zgc:76973Protein level used designations for PTPN2
- T-cell protein tyrosine phosphatase
- tyrosine-protein phosphatase non-receptor type 2
- MPTP
- T cell protein-tyrosine phosphatase
- protein-tyrosine phosphatase PTP-2
- protein-tyrosine phosphatase PTP-S
- phosphoprotein phosphatase
- protein tyrosine phosphatase 1B
- protein tyrosine phosphatase, non-receptor type 2, like
- protein tyrosine phosphatase, non-receptor type 2, a
- protein tyrosine phosphatase, non-receptor type 2 L homeolog
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