PSMC1 产品
(Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 1 (PSMC1))
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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008].
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Featured PSMC1 Categories
Recommended PSMC1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA
Validations
- (3)
Cat. No.
ABIN7237615
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p), IF
Validations
- (3)
- (3)
Cat. No.
ABIN1881692
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (2)
Cat. No.
ABIN7442210
Quantity
100 μL
Datasheet
Datasheet
Recommended PSMC1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6229234
Quantity
96 tests
Datasheet
Datasheet
Recommended PSMC1 蛋白
Latest Publications for our PSMC1 Products
: "Global profiling of co- and post-translationally N-myristoylated proteomes in human cells." in: Nature communications, Vol. 5, pp. 4919, (2014) (PubMed).: "A complex between peptide:N-glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 38, pp. 13774-9, (2004) (PubMed).
: "Association of ataxin-7 with the proteasome subunit S4 of the 19S regulatory complex." in: Human molecular genetics, Vol. 10, Issue 24, pp. 2821-31, (2001) (PubMed).
: "Subunit 4 of the 26 S protease is a member of a novel eukaryotic ATPase family." in: The Journal of biological chemistry, Vol. 267, Issue 32, pp. 22699-702, (1992) (PubMed).
Synonyms and alternative names related to PSMC1
protease (prosome, macropain) 26S subunit, ATPase 1 (Psmc1), proteasome 26S subunit, ATPase 1 (PSMC1), proteasome 26S subunit, ATPase 1 (Psmc1), AI325227, P26s4, P26S4, p56, S4, s4Protein level used designations for PSMC1
- 26S protease regulatory subunit 4
- 26S proteasome AAA-ATPase subunit RPT2
- proteasome 26S subunit ATPase 1
- proteasome 26S ATPase subunit 1
- proteasome 26S subunit, ATPase, 1
- P26s4
- peptidase (prosome, macropain) 26S subunit, ATPase 1
- protease (prosome, macropain) 26S subunit, ATPase 1
- 26S ATPase complex subunit 4
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