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PSIP1 产品

(PC4 and SFRS1 Interacting Protein 1 (PSIP1))
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity).

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Featured PSIP1 Categories

PSIP1 抗体

High quality antibodies with extensive validation data.

PSIP1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

PSIP1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PSIP1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Monkey, Rat
Application WB, IHC, ELISA, ICC
Validations
  • (1)
  • (5)
Cat. No. ABIN969370
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (1)
  • (4)
Cat. No. ABIN564851
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (4)
Cat. No. ABIN524600
Quantity 100 μg
Datasheet Datasheet

Recommended PSIP1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969165
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1147116
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1147117
Quantity 96 tests
Datasheet Datasheet

Recommended PSIP1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1316542
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7424704
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7405540
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our PSIP1 Products

Nakamura, Campbell, Moore, Otsu, Aikawa, Tamamura, Mitsuya: "Development and validation of a cell-based assay system to assess human immunodeficiency virus type 1 integrase multimerization." in: Journal of virological methods, Vol. 236, pp. 196-206, (2016) (PubMed).

Leoh, van Heertum, De Rijck, Filippova, Rios-Colon, Basu, Martinez, Tungteakkhun, Filippov, Christ, De Leon, Debyser, Casiano: "The stress oncoprotein LEDGF/p75 interacts with the methyl CpG binding protein MeCP2 and influences its transcriptional activity." in: Molecular cancer research : MCR, Vol. 10, Issue 3, pp. 378-91, (2012) (PubMed).

Basu, Rojas, Banerjee, Cabrera, Perez, De León, Casiano: "Expression of the stress response oncoprotein LEDGF/p75 in human cancer: a study of 21 tumor types." in: PLoS ONE, Vol. 7, Issue 1, pp. e30132, (2012) (PubMed).

Pradeepa, Sutherland, Ule, Grimes, Bickmore: "Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing." in: PLoS genetics, Vol. 8, Issue 5, pp. e1002717, (2012) (PubMed).

Desimmie, Humbert, Lescrinier, Hendrix, Vets, Gijsbers, Ruprecht, Dietrich, Debyser, Christ: "Phage display-directed discovery of LEDGF/p75 binding cyclic peptide inhibitors of HIV replication." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 20, Issue 11, pp. 2064-75, (2012) (PubMed).

Basu, Drame, Muñoz, Gijsbers, Debyser, De Leon, Casiano: "Pathway specific gene expression profiling reveals oxidative stress genes potentially regulated by transcription co-activator LEDGF/p75 in prostate cancer cells." in: The Prostate, Vol. 72, Issue 6, pp. 597-611, (2012) (PubMed).

Hendrix, Gijsbers, De Rijck, Voet, Hotta, McNeely, Hofkens, Debyser, Engelborghs: "The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering." in: Nucleic acids research, Vol. 39, Issue 4, pp. 1310-25, (2011) (PubMed).

Gijsbers, Vets, De Rijck, Ocwieja, Ronen, Malani, Bushman, Debyser: "Role of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targeting." in: The Journal of biological chemistry, Vol. 286, Issue 48, pp. 41812-25, (2011) (PubMed).

Lin, Yu, Yang, Liu, Karia, Bishop, Jackson, Lozano, Copland, Mu, Sun, Sun: "Mutant p53 disrupts role of ShcA protein in balancing Smad protein-dependent and -independent signaling activity of transforming growth factor-β (TGF-β)." in: The Journal of biological chemistry, Vol. 286, Issue 51, pp. 44023-34, (2011) (PubMed).

De Rijck, Bartholomeeusen, Ceulemans, Debyser, Gijsbers: "High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region." in: Nucleic acids research, Vol. 38, Issue 18, pp. 6135-47, (2010) (PubMed).

Synonyms and alternative names related to PSIP1

PC4 and SFRS1 interacting protein 1 S homeolog (psip1.S), PC4 and SFRS1 interacting protein 1 (PSIP1), PC4 and SFRS1 interacting protein 1a (psip1a), PC4 and SFRS1 interacting protein 1 (psip1), LEDGF/p75 transcription factor-like (psip1), PC4 and SFRS1 interacting protein 1 (Psip1), AA408851, AU015605, DFS70, Dfs70, im:7149861, LEDGF, Ledgf, LEDGF/p75, Ledgfa, Ledgfb, p52, p75, PAIP, PSIP1, PSIP2, Psip2, SBP75, zgc:109898

Protein level used designations for PSIP1

  • PC4 and SFRS1 interacting protein 1
  • LEDGF/p75
  • PC4 and SFRS1-interacting protein
  • PC4 and SFRS1-interacting protein-like protein
  • Lens epithelium-derived growth factor
  • PC4 and SFRS1-interacting protein-like
  • putative LEDGF/p75 transcription factor
  • lens epithelium-derived growth factor
  • CLL-associated antigen KW-7
  • DFS 70
  • dense fine speckles 70 kDa protein
  • transcriptional coactivator p52/p75
  • transcriptional coactivator p75/p52
  • PC4 and SFRS1 interacting protein 2
  • dense fine speckles 70
  • mLEDGF
  • supercoiled DNA binding protein 75
  • lens epithelium derived growth factor p75
  • transcription coactivator p75
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