KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKSNNRQVC IDPKLKWIQE YLDKALNKRL K
产品特性
Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human peripheral blood monocytes is less than 200 ng/ml, corresponding to a specific activity of >, 5.0 × 103 IU/mg.
纯度
> 97 % by SDS-PAGE and HPLC analyses.
内毒素水平
Level Less than 1EU/µg of rRtSDF-1beta/CXCL12 as determined by LAL method
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.
SDF-1ª and beta are stromal derived CXC chemokines, and signal through the CXCR4 receptor. SDF-1ª and beta chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV suppressive activity in cells expressing the CXCR4 receptor. Synonym: SDF-1beta/CXCL12, Rat. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 150mM NaCl.
分子量
7.9 kDa, a single non-glycosylated polypeptide chain containing 72 amino acids.