NOG 蛋白
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- 抗原 See all NOG 蛋白
- NOG (Noggin (NOG))
- 生物活性
- Active
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 序列
- MQHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGAAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS FWPRYVKVGS CFSKRSCSVP EGMVCKPSKS VHLTVLRWRC QRRGGQRCGW IPIQYPIISE CKCS
- 产品特性
- Fully biologically active when compared to standard. The ED50 determined by inhibiting BMP-4-induced alkaline phosphatase production ofmurine ATDC5 cells is less than 80 ng/ml, corresponding to a specific activity of >1.3×104 IU/mg in the presence of 5ng/ml BMP-4.
- 纯度
- > 95 % by SDS-PAGE and HPLC analyses.
- 内毒素水平
- Level Less than 1EU/µg of rHu NOGGIN as determined by LAL method
- Top Product
- Discover our top product NOG 蛋白
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Noggin (NOG) (AA 20-232) (Active) protein
NOG 宿主: 小鼠 宿主: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active
Noggin (NOG) proteinNOG 宿主: 人 宿主: CHO Cells Recombinant > 95% as determined by Tris-Bis PAGE
Noggin (NOG) (AA 28-232) (Active) proteinNOG 宿主: 人 宿主: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active
Noggin (NOG) protein (His tag)NOG 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
Noggin (NOG) (AA 28-232) protein (His tag)NOG 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Noggin (NOG) (AA 28-232) protein (GST tag)NOG 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Noggin (NOG) protein (Fc Tag)NOG 宿主: 人 宿主: HEK-293 Cells Recombinant Greater than 95 % as determined by reducing SDS-PAGE.
Noggin (NOG) (AA 28-232) protein (Fc Tag)NOG 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 10mM HAc to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at
- 储存条件
- 4 °C
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- 抗原
- NOG (Noggin (NOG))
- 别名
- NOGGIN (NOG 产品)
- 别名
- SYM1 Protein, SYNS1 Protein, nog-A Protein, nog1 Protein, noggin-1 Protein, noggin Protein, noggin Protein, noggin L homeolog Protein, noggin protein Protein, NOG Protein, Nog Protein, nog.L Protein, noggin Protein
- 背景
- Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-beta family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Synonym: NOGGIN, Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 30% acetonitrile, 0.1% TFA.
- 分子量
- Approximately 46.2 kDa non-disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains.
- 途径
- Stem Cell Maintenance, Tube Formation
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