MICB 蛋白
-
- 抗原 See all MICB 蛋白
- MICB (MHC Class I Polypeptide-Related Sequence B (MICB))
- 生物活性
- Active
- 宿主
- 人
-
资源
- 大肠杆菌（E. Coli）
- 应用范围
- ELISA
- 产品特性
- Measured by its ability to bind MICB antibody in a ELISA.
- 纯度
- > 95 % by SDS-PAGE and HPLC analyses.
- 内毒素水平
- Level Less than 1EU/µg of rHuMIC-B as determined by LAL method
- Top Product
- Discover our top product MICB 蛋白
-
MHC Class I Polypeptide-Related Sequence B (MICB) (AA 23-309) protein (His tag)
MICB 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
MHC Class I Polypeptide-Related Sequence B (MICB) (AA 23-298) protein (His-Avi Tag)MICB 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
MHC Class I Polypeptide-Related Sequence B (MICB) protein (His-Avi Tag,Biotin)MICB 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
MHC Class I Polypeptide-Related Sequence B (MICB) (AA 1-340) protein (GST tag)MICB 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
MHC Class I Polypeptide-Related Sequence B (MICB) (AA 121-220) protein (GST tag)MICB 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20°C. Further dilutions should be made in appropriate buffered solutions.
- 储存条件
- 4 °C
-
- 抗原
- MICB (MHC Class I Polypeptide-Related Sequence B (MICB))
- 别名
- MIC-B (MICB 产品)
- 别名
- PERB11.2 Protein, MHC class I polypeptide-related sequence B Protein, MHC class I-related protein-like Protein, MICB Protein, LOC512825 Protein
- 背景
- MIC-B (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MIC-A, shares 85% amino acid identity with MIC-B. These 2 proteins are distantly related to the MHC class I proteins. MIC-A and MIC-B (MIC-A/B) possess three extracellular immunoglobulin-like domains, but have no capacity to bind peptide or interact with beta2-microglobulin. The genes encoding MIC-A/B are found within the major histocompatibility complex on human chromosome 6. The MIC-B locus is polymorphic with more than 15 recognized human alleles. MIC-A/B are minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MIC-A/B are ligands for NKG2D, an activating receptor expressed on NK cells, NKT cells, γδ T cells, and CD8+ abeta T cells. Recognition of MIC-A/B by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MIC-A/B recognition is involved in tumor surveillance, viral infections, and autoimmune diseases. The release of soluble forms of MIC-A/B from tumors down-regulates NKG2D surface expression on effector cells resulting in the impairment of anti-tumor immune response. Synonym:. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.
- 分子量
- Approximately 37 kDa, 326 amino acid residues containing the extracellular domain of mature human MICB (amino acid residues Ala23 â Tyr312).100µg /1000µg
- 途径
- Human Leukocyte Antigen (HLA) in Adaptive Immune Response
-
