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MICB 蛋白

MICB 宿主: 人 宿主: 大肠杆菌(E. Coli) > 95 % by SDS-PAGE and HPLC analyses. ELISA Active
产品编号 ABIN988150
发货至: 中国
  • 抗原 See all MICB 蛋白
    MICB (MHC Class I Polypeptide-Related Sequence B (MICB))
    生物活性
    Active
    宿主
    资源
    • 8
    • 2
    • 1
    大肠杆菌(E. Coli)
    应用范围
    ELISA
    产品特性
    Measured by its ability to bind MICB antibody in a ELISA.
    纯度
    > 95 % by SDS-PAGE and HPLC analyses.
    内毒素水平
    Level Less than 1EU/µg of rHuMIC-B as determined by LAL method
    Top Product
    Discover our top product MICB 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20°C. Further dilutions should be made in appropriate buffered solutions.
    储存条件
    4 °C
  • 抗原
    MICB (MHC Class I Polypeptide-Related Sequence B (MICB))
    别名
    MIC-B (MICB 产品)
    别名
    PERB11.2 Protein, MHC class I polypeptide-related sequence B Protein, MHC class I-related protein-like Protein, MICB Protein, LOC512825 Protein
    背景
    MIC-B (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MIC-A, shares 85% amino acid identity with MIC-B. These 2 proteins are distantly related to the MHC class I proteins. MIC-A and MIC-B (MIC-A/B) possess three extracellular immunoglobulin-like domains, but have no capacity to bind peptide or interact with beta2-microglobulin. The genes encoding MIC-A/B are found within the major histocompatibility complex on human chromosome 6. The MIC-B locus is polymorphic with more than 15 recognized human alleles. MIC-A/B are minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MIC-A/B are ligands for NKG2D, an activating receptor expressed on NK cells, NKT cells, γδ T cells, and CD8+ abeta T cells. Recognition of MIC-A/B by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MIC-A/B recognition is involved in tumor surveillance, viral infections, and autoimmune diseases. The release of soluble forms of MIC-A/B from tumors down-regulates NKG2D surface expression on effector cells resulting in the impairment of anti-tumor immune response. Synonym:. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.
    分子量
    Approximately 37 kDa, 326 amino acid residues containing the extracellular domain of mature human MICB (amino acid residues Ala23 – Tyr312).100µg /1000µg
    途径
    Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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