MICA 蛋白
-
- 抗原 See all MICA 蛋白
- MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
- 生物活性
- Active
-
宿主
- 人
-
资源
- 大肠杆菌（E. Coli）
- 应用范围
- ELISA
- 序列
- MSYYHHHHHH DYDIPTTENL YFQGAMAPEF EPHSLRYNLT VLSWDGSVQS GFLTEVHLDG QPFLRCDRQK CRAKPQGQWA EDVLGNKTWD RETRDLTGNG KDLRMTLAHI KDQKEGLHSL QEIRVCEIHE DNSTRSSQHF YYDGELFLSQ NLETKEWTMP QSSRAQTLAM NVRNFLKEDA MKTKTHYHAM HADCLQELRR YLKSGVVLRR TVPPMVNVTR SEASEGNITV TCRASGFYPW NITLSWRQDG VSLSHDTQQW GDVLPDGNGT YQTWVATRIC QGEEQRFTCY MEHSGNHSTH PVPSGKVLVL QSHW
- 产品特性
- Measured by its ability to bind MICA antibody in a ELISA.
- 纯度
- > 95 % by SDS-PAGE and HPLC analyses.
- 内毒素水平
- Level Less than 1EU/µg of rHuMIC-A as determined by LAL method
- Top Product
- Discover our top product MICA 蛋白
-
MHC Class I Polypeptide-Related Sequence A (MICA) protein (His-Avi Tag,Biotin)
MICA 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
MHC Class I Polypeptide-Related Sequence A (MICA) (AA 1-284) protein (His tag)MICA 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
MHC Class I Polypeptide-Related Sequence A (MICA) (AA 24-308) protein (His-Avi Tag)MICA 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
MHC Class I Polypeptide-Related Sequence A (MICA) (AA 24-307) protein (His tag)MICA 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
MHC Class I Polypeptide-Related Sequence A (MICA) (AA 24-308) (Active) protein (Fc Tag)MICA 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
MHC Class I Polypeptide-Related Sequence A (MICA) (AA 24-306) protein (His tag)MICA 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
MHC Class I Polypeptide-Related Sequence A (MICA) (AA 24-307) protein (His tag)MICA 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
MHC Class I Polypeptide-Related Sequence A (MICA) (AA 1-383) protein (GST tag)MICA 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.
- 储存条件
- 4 °C
-
- 抗原
- MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
- 别名
- MIC-A (MICA 产品)
- 别名
- MIC-A Protein, PERB11.1 Protein, MHC class I polypeptide-related sequence A Protein, MICA Protein
- 背景
- MIC-A (MHC class I chain-related gene A) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MICB, shares 85% amino acid identity with MICA. These proteins are distantly related to the MHC class I proteins. They possess three extracellular Ig-like domains, but they have no capacity to bind peptide or interact with beta2-microglobulin. The genes encoding these proteins are found within the Major Histocompatibility Complex on human chromosome 6. The MICA locus is highly polymorphic with more than 50 recognized human alleles. MICA is absent from most cells but is frequently expressed in epithelial tumors and can be induced by bacterial and viral infections. MICA is a ligand for human NKG2D, an activating receptor expressed on NK cells, NKT cells, γδ T cells, and CD8+ ªbeta T cells. Recognition of MICA by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MICA recognition is involved in tumor surveillance, viral infections, and autoimmune diseases. Synonym: MIC-A, Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.
- 分子量
- Approximately 36.5 kDa, a single non-glycosylated polypeptide chain containing 315 amino acids.
- 途径
- Activation of Innate immune Response, Transition Metal Ion Homeostasis, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
-
