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IL29 蛋白

IL29 宿主: 人 宿主: 大肠杆菌(E. Coli) > 97 % by SDS-PAGE and HPLC analyses. Active
产品编号 ABIN988002
发货至: 中国
  • 抗原 See all IL29 蛋白
    IL29 (Interleukin 29 (IL29))
    生物活性
    Active
    宿主
    • 12
    • 1
    资源
    • 7
    • 4
    • 1
    大肠杆菌(E. Coli)
    序列
    GPVPTSKPTT TGKGCHIGRF KSLSPQELAS FKKARDALEE SLKLKNWSCS SPVFPGNWDL RLLQVRERPV ALEAELALTL KVLEAAAGPA LEDVLDQPLH TLHHILSQLQ ACIQPQPTAG PRPRGRLHHW LHRLQEAPKK ESAGCLEASV TFNLFRLLTR DLKYVADGNL CLRTSTHPES
    产品特性
    Fully biologically active when compared to standard. The ED50 is determined in an anti-viral assay using human HepG2 cells infected with encephalomyocarditis is typically 1-5 ng/ml,corresponding to a specific activity of > 2.0×105 units/mg.
    纯度
    > 97 % by SDS-PAGE and HPLC analyses.
    内毒素水平
    Level Less than 1EU/µg of rHuIFN-lambda1 as determined by LAL method
    Top Product
    Discover our top product IL29 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.
    储存条件
    4 °C
  • 抗原
    IL29 (Interleukin 29 (IL29))
    别名
    Interferon-Lambda1 (IFN-Lambda1) (IL29 产品)
    别名
    IL-29 Protein, IL29 Protein, interferon lambda 1 Protein, interferon lambda-1 Protein, interleukin 29 (interferon, lambda 1) Protein, IFNL1 Protein, LOC612539 Protein, IL29 Protein
    背景
    IL-28A, IL-28B, and IL-29, also named interferon-lambda2 (IFN-lambda2), IFN-lambda3, and IFN-lambda1, respectively, are newly identified class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11-13% aa sequence identity) and the type I IFN family (15-19% aa sequence identity). The expression of IL-28A, B, and IL-29 is induced by virus infection or double-stranded RNA. All three cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The three proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor beta (IL-10 Rbeta) and a novel IL-28 receptor alpha (IL-28 Ralpha, also known as IFN-lambdaR1). Ligand binding to the receptor complex induces Jak kinase activation and STAT1 and STAT2 tyrosine phosphorylation. Synonym: Interferon-lambda1 ( IFN-lambda1), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 130mM NaCl.
    分子量
    Approximately 19.8 kDa, a single non-glycosylated polypeptide chain containing 181 amino acids.
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