Purified recombinant Human IL1 beta protein Expression System: E.coli Bioactivity: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by Mouse D10S cells is ? 1.0 pg/mL, corresponding to a specific activity of ? 1 x 10^9 units/mg.
IL1beta is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL1a and IL1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL2 release, B-cell maturation and proliferation, mitogenic FGFlike activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL1beta is a secreted cytokine, IL1a is predominantly a cell-associated cytokine. Alternative Names: LAF protein, IL-1 beta protein, IL 1, Leukocyte Endogenous Mediator protein, IL-1 protein, Catabolin protein, IL-1, Lymphocyte-activating factor protein, EP protein, Mononuclear Cell Factor protein, Endogenous Pyrogen protein, Interleukin 1 beta protein, LEM protein, IL 1 protein, IL1, MCF protein