CPN10 Protein, EPF Protein, GROES Protein, HSP10 Protein, groS Protein, Cpn10 Protein, cpn10 Protein, zgc:86747 Protein, hspe1 Protein, MGC89647 Protein, HSPE1 Protein, MITOCHONDRIAL CHAPERONIN 10 Protein, T15D22.2 Protein, T15D22_2 Protein, chaperonin 10 Protein, Dmel\\CG11267 Protein, Hsp10 Protein, anon-WO0118547.175 Protein, hsp10 Protein, crpB Protein, chpS Protein, 10kDa Protein, mt-cpn10 Protein, heat shock protein family E (Hsp10) member 1 Protein, molecular chaperone GroES Protein, chaperonin 10 kDa Protein, chaperonin, 10 kDa Protein, chaperonin-10 kDa Protein, heat shock protein family E member 1 Protein, heat shock 10 protein 1 Protein, heat shock protein family E (Hsp10) member 1 L homeolog Protein, heat shock 10kDa protein 1 (chaperonin 10) pseudogene Protein, 10 kd chaperonin Protein, chaperonin 10 Protein, Hsp10p Protein, co-chaperonin 10, mitochondrial Protein, CG11267 gene product from transcript CG11267-RA Protein, co-chaperonin GroES Protein, mitochondrial heat shock protein Hsp10 (predicted) Protein, chaperonin GroS Protein, Hsp10 10 kDa chaperonin GROES Protein, mitochondrial heat shock protein Hsp10 Protein, heat shock protein 10 Protein, heat shock protein 1 (chaperonin 10) Protein, heat shock 10kDa protein 1 (chaperonin 10) Protein, HSPE1 Protein, groES Protein, groES2 Protein, TP01_0190 Protein, Cag_1167 Protein, Bm1_56470 Protein, Hspe1 Protein, hspe1 Protein, hspe1.L Protein, LOC452179 Protein, Cpn10 Protein, CPN10 Protein, HSP10 Protein, CG11267 Protein, hsp10 Protein, groS Protein
背景
Heat shock protein (HSP) 10 is a member of the highly conserved group of molecular chaperons, which are necessary for efficient folding of many proteins in normal and stress conditions and have been implicated in several human diseases. HSP10 is the ~10kD mammalian equivalent to GroES of E. coli. The function of Hsp10 is to bind Hsp60 (also known as chaperonin-60), in the presence of ATP, thereby promoting a conformational change in Hsp60 and enclosing the protein substrate within the complex. ATP hydrolysis by Hsp60 destabilizes the Hsp60/ Hsp10 complex, allowing it to dissociate and release the substrate protein. Recombinant human HSP10 was expressed in E. coli and purified by using conventional chromatography techniques. Alternative Names: HSP-10, HSP10 protein, Cpn 10 protein, HSPE1 protein, 10 kDa heat shock protein mitochondrial protein, Heat shock 10kD protein 1 protein, CPN10 protein, Heat shock 10kDa protein 1 chaperonin 10 protein, HSP 10 protein, HSP-10 protein, Heat shock 10kDa protein 1 protein, HSP 10 protein, HSP10 protein, , HSP10, Heat shock 10kD protein 1 chaperonin 10 protein, HSP 10, Early pregnancy factor protein, Heat shock protein 10 10 kDa chaperonin protein, Chaperonin 10 protein, Heat shock protein 10 protein, HSPE 1 protein, GroES protein, EPF protein