Caspase 1 Protein (CASP1)
Quick Overview for Caspase 1 Protein (CASP1) (ABIN925024)
抗原
See all Caspase 1 (CASP1) 蛋白蛋白类型
生物活性
宿主
资源
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产品特性
- ~8000 units/mg. One unit cleaves 1 nmol of the caspase substrate YVAD-pNA per hour at 37°C in a reaction solution containing 50 mM HEPES, pH 7.2, 50 mM NaCl, 0.1% CHAPS, 10mM EDTA, 5% glycerol and 10 mM DTT.
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Caspase 1 (CASP1) (AA 120-269) protein (His tag)
CASP1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Caspase 1 (CASP1) (AA 120-404) protein (His tag)CASP1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Caspase 1 (CASP1) (AA 1-311) protein (GST tag)CASP1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Caspase 1 (CASP1) (AA 1-100) protein (GST tag)CASP1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Caspase 1 (CASP1) (AA 120-269), (partial) protein (GST tag)CASP1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 90 % ELISA
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstitute with PBS to 1 unit/µl.
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储存条件
- -80 °C
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- Caspase 1 (CASP1)
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别名
- Caspase-1
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背景
- Caspase-1 (also known as ICE, Interleulin-1- Converting Enzyme) is the prototypical member of the caspase family of cysteine proteases. Caspase-1 exists in cells as an inactive 45 kDa pro-enzyme. The pro-enzyme is matured by proteolysis to yield large (20 kDa) and small (10 kDa) subunits. The active enzyme is a heterotetramer consisting of two large and two small subunits. To date the mechanism of regulation of caspase-1 activation is complex and poorly understood. In THP-1 cells, a large proportion of the caspase-1 is present in the inactive pro-enzyme form.
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分子量
- 45 kDa
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途径
- Apoptosis, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome
抗原
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