PARP2 蛋白
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- 抗原 See all PARP2 蛋白
- PARP2 (Poly (ADP-Ribose) Polymerase 2 (PARP2))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- Insect cells (Sf9)
- 产品特性
- 380 units/mg (one unit synthesizes 1 nmole of poly(ADP-ribose) per min at 25°C, pH 7.5.
- 纯化方法
- Affinity purified
- 纯度
- 98 % (SDS-PAGE).
- Top Product
- Discover our top product PARP2 蛋白
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Poly (ADP-Ribose) Polymerase 2 (PARP2) protein (His tag)
PARP2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 85 % by SDS - PAGE SDS
Poly (ADP-Ribose) Polymerase 2 (PARP2) (AA 430-583) protein (His-IF2DI Tag)PARP2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Poly (ADP-Ribose) Polymerase 2 (PARP2) (AA 435-534) protein (GST tag)PARP2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 储存条件
- -80 °C
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- 抗原
- PARP2 (Poly (ADP-Ribose) Polymerase 2 (PARP2))
- 别名
- PARP-2 (PARP2 产品)
- 别名
- ADPRT2 Protein, ADPRTL2 Protein, ADPRTL3 Protein, ARTD2 Protein, PARP-2 Protein, pADPRT-2 Protein, Adprt2 Protein, Adprtl2 Protein, Aspartl2 Protein, C78626 Protein, cb996 Protein, adprtl2 Protein, ADPRT-2 Protein, APP Protein, ATPARP1 Protein, PARP1 Protein, POLY(ADP-RIBOSE) POLYMERASE Protein, POLY(ADP-RIBOSE) POLYMERASE 1 Protein, PP Protein, T14P8.19 Protein, T14P8_19 Protein, poly(ADP-ribose) polymerase Protein, poly(ADP-ribose) polymerase 2 Protein, poly(ADP-ribose) polymerase 2 Protein, poly (ADP-ribose) polymerase family, member 2 Protein, poly (ADP-ribose) polymerase 2 Protein, poly(ADP-ribose) polymerase 2 S homeolog Protein, poly(ADP-ribose) polymerase Protein, PARP2 Protein, Parp2 Protein, parp2 Protein, parp2.S Protein
- 背景
- The cDNA encoding human poly(ADP-ribose) polymerase (PARP) was cloned by several groups simultaneously. With the discovery of new members (homologs) of the PARP family, PARP is newly referred to as PARP-1. The isolated cDNAs from mouse and human encode a protein with considerable homology to the catalytic domain of PARP-1. This protein, termed PARP-2, is a 64 kDa protein that contains a nuclear localization signal (NLS) and is activated by DNA breaks, although its DNA- binding domain is very different from that of PARP-1. In recent years evidence has accumulated that poly(ADP-ribose) polymerase (PARP) plays a role in DNA repair and a substantial effort has been invested to elucidate the physiological function of the PARP pathway in cellular recovery from DNA damage. PARP has been found in the base excision repair (BER) complex with DNA polymerase-, ligase III and x-ray repair cross-complementing 1 (XRCC1). PARP- 1 and PARP-2, even though lacking the zinc- finger domains, bind to single and double strand breaks during oxidative stress. In general, it appears that an early enzymatic activation of PARP occurs upon DNA-strand break formation. Binding of PARP to a DNA nick may then cause a transient halt to cellular activity and protect the DNA from sister chromatid associated proteins such as histones. Nicotinamide is cleaved in this step from the substrate NAD+ by PARP and the so synthesized poly(ADP)-ribose (PAR) is then used to generate ATP. Specific
- 途径
- DNA Damage Repair
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