DNAJB9 蛋白
This Recombinant DNAJB9 protein is expressed in 大肠杆菌（E. Coli）.
产品编号 ABIN7539341
发货至:
中国
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Quick Overview for DNAJB9 蛋白 (ABIN7539341)
抗原
See all DNAJB9 蛋白
DNAJB9
(Microvascular Endothelial Differentiation Gene 1 Protein (DNAJB9))
蛋白类型
Recombinant
宿主
人
资源
大肠杆菌（E. Coli）
纯度
> 95 % by SDS-PAGE
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原理
- Mdg-1
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序列
- MKHHHHHHSA GLEVLFQGPM ASKSYYDTLG VPKSASERQI KKAFHKLAMK YHPDKNKSPD AEAKFREIAE AYETLSDANR RKEYDTLGHS AFTSGKGQRG SGSSFEQSFN FNFDDLFKDF GFFGQNQNTG SKKRFENHFQ TRQDGGSSRQ RHHFQEFSFG GGLFDDMFED MEKMFSFSGF DSTNQHTVQT ENRFHGSSKH CRTVTQRRGN MVTTYTDCSG Q
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产品特性
- Length (aa):221
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Microvascular Endothelial Differentiation Gene 1 Protein (DNAJB9) (AA 1-223) protein (GST tag)
DNAJB9 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
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限制
- 仅限研究用
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状态
- Lyophilized
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- DNAJB9 (Microvascular Endothelial Differentiation Gene 1 Protein (DNAJB9))
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别名
- Mdg-1
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背景
- Microvascular endothelial differentiation gene 1 protein, DnaJ homolog subfamily B member 9, ERdj4,Angiogenesis research has focused on receptors and ligands mediating endothelial cell proliferation and migration. Little is known about the molecular mechanisms that are involved in converting endothelial cells from a proliferative to a differentiated state. Microvascular differentiation gene 1 (Mdg1) has been isolated from differentiating microvascular endothelial cells that had been cultured in collagen type I gels (3D culture). In adult human tissue Mdg1 is expressed in endothelial and epithelial cells. Sequence analysis of the full-length cDNA revealed that the N-terminal region of the putative Mdg1-protein exhibits a high sequence similarity to the J-domain of Hsp40 chaperones. It was shown that this region functions as a bona fide J-domain as it can replace the J-domain of Escherichia coli DnaJ-protein. Mdg1 is also upregulated in primary endothelial and mesangial cells when subjected to various stress stimuli. GFP-Mdg1 fusion constructs showed the Mdg1-protein to be localized within the cytoplasm under control conditions. Stress induces the translocation of Mdg1 into the nucleus, where it accumulates in nucleoli. Costaining with Hdj1, Hdj2, Hsp70, and Hsc70 revealed that Mdg1 colocalizes with Hsp70 and Hdj1 in control and stressed HeLa cells. These data suggest that Mdg1 is involved in the control of cell cycle arrest taking place during terminal cell differentiation and under stress conditions.
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分子量
- 25.3 kDa
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基因ID
- 4189
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NCBI登录号
- NM_012328, NP_036460
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UniProt
- Q9UBS3
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途径
- ER-Nucleus Signaling
抗原
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