Endothelin 1 Protein (EDN1) (His tag)
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- 抗原 See all Endothelin 1 (EDN1) 蛋白
- Endothelin 1 (EDN1)
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This Endothelin 1 protein is labelled with His tag.
- 原理
- Endothelin-1/ET-1
- 序列
- MAPETAVLGA ELSAVGENGG EKPTPSPPWR LRRSKRCSCS SLMDKECVYF CHLDIIWVNT PEHVVPYGLG SPRSKRALEN LLPTKATDRE NRCQCASQKD KKCWNFCQAG KELRAEDIME KDWNNHKKGK DCSKLGKKCI YQQLVRGRKI RRSSEEHLRQ TRSETMRNSV KSSFHDPKLK GKPSRERYVT HNRAHWLEHH HHHH
- 产品特性
- Length (aa):204
- 纯度
- > 98 % by SDS-PAGE and visualized Coomassie stain
- Top Product
- Discover our top product EDN1 蛋白
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Endothelin 1 (EDN1) (AA 113-212) protein (GST tag)
EDN1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Endothelin 1 (EDN1) (AA 54-202) (Active) protein (His tag)EDN1 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） > 95 % AcA, CC Active
Endothelin 1 (EDN1) (AA 53-90) protein (His-IF2DI Tag)EDN1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA
Endothelin 1 (EDN1) (AA 1-212) protein (GST tag)EDN1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Endothelin 1 (EDN1) (AA 53-73) (Active) protein (GST tag)EDN1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 90 % ELISA Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- water
- 缓冲液
- PBS
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- 抗原
- Endothelin 1 (EDN1)
- 别名
- Endothelin-1/ET-1 (EDN1 产品)
- 别名
- et1 Protein, et-1 Protein, Edn1 Protein, EDN Protein, ET-1 Protein, ET1 Protein, PPET1 Protein, HDLCQ7 Protein, preproET Protein, Et1 Protein, fb14d01 Protein, wu:fb14d01 Protein, PPET-1 Protein, EDN1 Protein, edn1 Protein, edn1-a Protein, edn1-b Protein, endothelin 1 Protein, endothelin 1 S homeolog Protein, endothelin 1 L homeolog Protein, edn1 Protein, EDN1 Protein, Edn1 Protein, edn1.S Protein, edn1.L Protein
- 背景
- Preproendothelin-1, PPET-1, ET-1, EDN1,Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. ET-1 acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion. A recent study has shown that ET-1 is involved in the activation of transcription factors such as NF-kappaB and expression of proinflammatory cytokines including TNF-alpha, IL-1, and IL-6. It has been also indicated that during endotoxaemia, the plasma level of ET-1 is increased in various animal species. Some authors indicate a clear correlation between endothelin plasma level and morbidity/mortality rate in septic patients. These pathological effects of ET-1 may be abrogated at least partly by endothelin receptor blockade. ET-1 receptor antagonists may be useful for prevention of various vascular diseases.
- 分子量
- 26.0 kDa
- 基因ID
- 1906
- NCBI登录号
- NM_01955, NP_001946
- UniProt
- P05305
- 途径
- Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Cell Size
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