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- 抗原 See all TLR7 蛋白
- TLR7 (Toll-Like Receptor 7 (TLR7))
- 蛋白类型
- Synthetic Nanodisc
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宿主
- 人
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资源
- Mammalian Cells
- 原理
- Human TLR7 full length protein-synthetic nanodisc
- 产品特性
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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Toll-Like Receptor 7 (TLR7) (AA 27-126) protein (GST tag)
TLR7 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Toll-Like Receptor 7 (TLR7) (AA 27-348), (partial) protein (GST tag)TLR7 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
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- 说明
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- TLR7 (Toll-Like Receptor 7 (TLR7))
- 别名
- TLR7 (TLR7 产品)
- 别名
- TLR7-like Protein, RGD1563357 Protein, toll like receptor 7 Protein, toll-like receptor 7 Protein, TLR7 Protein, Tlr7 Protein
- 背景
- The protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. For the recognition of structural components in foreign microorganisms, the various TLRs exhibit different patterns of expression as well, in this way for example, TLR-3, -7, and -8 are essential in the recognition of single-stranded RNA viruses. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells.
- 分子量
- The human full length TLR7 protein has a MW of 120.9 kDa
- UniProt
- Q9NYK1
- 途径
- TLR signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades
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