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- 抗原 See all TLR5 蛋白
- TLR5 (Toll-Like Receptor 5 (TLR5))
- 蛋白类型
- Synthetic Nanodisc
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宿主
- 人
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资源
- Mammalian Cells
- 原理
- Human TLR5 full length protein-synthetic nanodisc
- 产品特性
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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Toll-Like Receptor 5 (TLR5) (AA 517-634) protein (GST tag)
TLR5 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Toll-Like Receptor 5 (TLR5) (AA 351-450) protein (GST tag)TLR5 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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- 说明
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- TLR5 (Toll-Like Receptor 5 (TLR5))
- 别名
- TLR5 (TLR5 产品)
- 别名
- SLEB1 Protein, TIL3 Protein, TLR-5 Protein, sleb1 Protein, til3 Protein, tlr-5 Protein, tlr5 Protein, toll like receptor 5 Protein, toll-like receptor 5 Protein, toll like receptor 5 L homeolog Protein, toll-like receptor 5b Protein, TLR5 Protein, Tlr5 Protein, tlr5.L Protein, tlr-5 Protein, tlr5b Protein
- 背景
- Toll-like receptor (TLR) family plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.
- 分子量
- The human full length TLR5 protein has a MW of 97.8 kDa
- UniProt
- O60602
- 途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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