OPN4 蛋白
OPN4
宿主: 人
宿主: Mammalian Cells
Synthetic Nanodisc
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- 抗原 See all OPN4 蛋白
- OPN4 (Opsin 4 (OPN4))
- 蛋白类型
- Synthetic Nanodisc
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宿主
- 人
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资源
- Mammalian Cells
- 原理
- Human OPN4 full length protein-synthetic nanodisc
- 产品特性
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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- 说明
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- OPN4 (Opsin 4 (OPN4))
- 别名
- OPN4 (OPN4 产品)
- 别名
- MOP Protein, 1110007J02Rik Protein, Gm533 Protein, OPN4-2 Protein, cOpn4L Protein, melanopsin Protein, opn4-A Protein, Xmop Protein, opn4 Protein, opn4d Protein, opsin 4 Protein, opsin 4 (melanopsin) Protein, melanopsin Protein, melanopsin-B-like L homeolog Protein, opsin 4a (melanopsin) Protein, OPN4 Protein, Opn4 Protein, LOC100303707 Protein, LOC100485437.L Protein, opn4a Protein
- 背景
- Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- 分子量
- The human full length OPN4 protein has a MW of 52.6kDa
- UniProt
- Q9UHM6
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