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MUC16 Protein (AA 13810-14451) (His tag)

CA125 宿主: 人 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
产品编号 ABIN7538396
发货至: 中国
  • 抗原 See all MUC16 (CA125) 蛋白
    MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))
    蛋白类型
    Recombinant
    产品特性
    AA 13810-14451
    宿主
    • 16
    • 4
    • 2
    • 2
    资源
    • 15
    • 4
    • 2
    • 2
    • 1
    Mammalian Cells
    标记
    This MUC16 protein is labelled with His tag.
    原理
    Recombinant human MUC16(13810-14451) Protein with C-terminal 10xHis tag
    特异性
    MUC16 (Pro13810-Pro14451) 10xHis tag
    产品特性
    Extracellular Domain Protein
    纯化方法
    Purified from cell culture supernatant by affinity chromatography
    纯度
    The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
    Top Product
    Discover our top product CA125 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    储存条件
    -20 °C,-80 °C
    储存方法
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    有效期
    12 months
  • 抗原
    MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))
    别名
    MUC16 (CA125 产品)
    别名
    CA125 Protein, 1110008I14Rik Protein, Ca125 Protein, Gm1480 Protein, RGD1308422 Protein, MUC16 Protein, mucin 16, cell surface associated Protein, mucin 16 Protein, mucin-16 Protein, MUC16 Protein, Muc16 Protein, LOC476718 Protein, LOC712735 Protein
    背景
    This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. [provided by RefSeq, May 2017]
    分子量
    predicted molecular mass of 73.2 kDa after removal of the signal peptide. The apparent molecular mass of MUC16(13810-14451)-His is 100-130 kDa due to glycosylation.
    UniProt
    Q8WXI7
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