MC1 Receptor 蛋白
MC1R
宿主: 人
宿主: Mammalian Cells
Synthetic Nanodisc
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- 抗原 See all MC1 Receptor (MC1R) 蛋白
- MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))
- 蛋白类型
- Synthetic Nanodisc
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宿主
- 人
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资源
- Mammalian Cells
- 原理
- Human MSHR full length protein-synthetic nanodisc
- 产品特性
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
- Top Product
- Discover our top product MC1R 蛋白
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Melanocortin 1 Receptor (MC1R) (AA 1-100) protein (GST tag)
MC1R 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
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- 说明
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))
- 别名
- MSHR (MC1R 产品)
- 别名
- CMM5 Protein, MSH-R Protein, SHEP2 Protein, Mshra Protein, Tob Protein, e Protein, MC1-R Protein, MSHR Protein, mc1r Protein, MC1R Protein, TUBB3 Protein, melanocortin 1 receptor Protein, melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) Protein, MC1R Protein, Mc1r Protein, mc1r Protein, mc1r_par1 Protein
- 背景
- This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]
- 分子量
- The human full length MSHR protein has a MW of 34.7kDa
- UniProt
- Q01726
- 途径
- cAMP Metabolic Process, Feeding Behaviour
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