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HCAR2 蛋白

HCAR2 宿主: 人 宿主: Mammalian Cells Synthetic Nanodisc
产品编号 ABIN7538324
发货至: 中国
  • 抗原 See all HCAR2 products
    HCAR2 (Hydroxycarboxylic Acid Receptor 2 (HCAR2))
    蛋白类型
    Synthetic Nanodisc
    宿主
    • 2
    • 1
    资源
    • 2
    • 1
    Mammalian Cells
    原理
    Human HCAR2 full length protein-synthetic nanodisc
    产品特性
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
  • 说明

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    储存条件
    -20 °C,-80 °C
    储存方法
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    有效期
    12 months
  • 抗原
    HCAR2 (Hydroxycarboxylic Acid Receptor 2 (HCAR2))
    别名
    HCAR2 (HCAR2 产品)
    别名
    GPR109A Protein, HCA2 Protein, HM74a Protein, HM74b Protein, NIACR1 Protein, PUMAG Protein, Puma-g Protein, Gpr109a Protein, Gpr109b Protein, HM74 Protein, Hcar2 Protein, PUMA-G Protein, Pumag Protein, mHM74b Protein, HCAR2 Protein, HCAR3 Protein, hydroxycarboxylic acid receptor 2 Protein, HCAR2 Protein, Hcar2 Protein, LOC527744 Protein
    背景
    Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.[UniProtKB/Swiss-Prot Function]
    分子量
    The human full length HCAR2 protein has a MW of 41.9kDa
    UniProt
    Q8TDS4
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