Metabotropic Glutamate Receptor 1 蛋白
GRM1
宿主: 人
宿主: Mammalian Cells
Synthetic Nanodisc
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- 抗原 See all Metabotropic Glutamate Receptor 1 (GRM1) 蛋白
- Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))
- 蛋白类型
- Synthetic Nanodisc
- 宿主
- 人
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资源
- Mammalian Cells
- 原理
- Human GRM1 full length protein-synthetic nanodisc
- 产品特性
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
- Top Product
- Discover our top product GRM1 蛋白
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Glutamate Receptor, Metabotropic 1 (GRM1) (AA 387-486) protein (GST tag)
GRM1 宿主: 人 宿主: 小麦胚 Recombinant WB, AA, AP, ELISA
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- 说明
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))
- 别名
- GRM1 (GRM1 产品)
- 别名
- fj39d05 Protein, wu:fj39d05 Protein, si:ch211-51a19.1 Protein, Glura Protein, mGlutR Protein, GB18621 Protein, GPRC1A Protein, MGLU1 Protein, MGLUR1 Protein, SCAR13 Protein, 4930455H15Rik Protein, ENSMUSG00000075319 Protein, Gm10828 Protein, Gprc1a Protein, mGluR1 Protein, nmf373 Protein, rcw Protein, wobl Protein, glutamate metabotropic receptor 1 Protein, glutamate receptor, metabotropic 1a Protein, metabotropic glutamate receptor 1 Protein, glutamate receptor, metabotropic 1 Protein, GRM1 Protein, grm1a Protein, mGlutR1 Protein, Grm1 Protein
- 背景
- This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
- 分子量
- The human full length GRM1 protein has a MW of 132.4kDa
- UniProt
- Q13255
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