GPBAR1 蛋白
GPBAR1
宿主: 人
宿主: Mammalian Cells
Synthetic Nanodisc
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- 抗原 See all GPBAR1 蛋白
- GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))
- 蛋白类型
- Synthetic Nanodisc
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宿主
- 人
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资源
- Mammalian Cells
- 原理
- Human GPBAR full length protein-synthetic nanodisc
- 产品特性
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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- Discover our top product GPBAR1 蛋白
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G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) (AA 1-330) protein (GST tag)
GPBAR1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
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- 说明
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))
- 别名
- GPBAR (GPBAR1 产品)
- 别名
- BG37 Protein, GPCR19 Protein, GPR131 Protein, M-BAR Protein, TGR5 Protein, Tgr5 Protein, MGC84403 Protein, GPBAR1 Protein, Gpbar1 Protein, GPCR Protein, G protein-coupled bile acid receptor 1 Protein, G protein-coupled bile acid receptor 1 S homeolog Protein, GPBAR1 Protein, Gpbar1 Protein, gpbar1.S Protein
- 背景
- This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
- 分子量
- The human full length GPBAR protein has a MW of 35.2kDa
- UniProt
- Q8TDU6
- 途径
- WNT signaling, Hormone Transport, Sensory Perception of Sound
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