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- 抗原 See all Claudin 6 (CLDN6) 蛋白
- Claudin 6 (CLDN6)
- 蛋白类型
- MSP Nanodisc
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宿主
- 人
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资源
- Mammalian Cells
- 原理
- Human Claudin-6 full length protein membrane nanoparticles (MNPs)
- 产品特性
- Plasma membrane-coated nanoparticles (MNPs) have been used in various applications, including delivery of therapeutic agents and induction of immune responses et al. Unlike the conventional strategies, MNPs directly leverage intact and natural functions of cell membranes, and show high biocompatibility, specificity, and low side effects. Our optimized MNPs platform for the full-length membrane protein production uses membrane coating technology and a HEK293 based expression platform. The high-purity plasma membrane-coated nanoparticles were produced by extrusion after membrane extraction from the host HEK293 cells containing the overexpressed target proteins.
- Top Product
- Discover our top product CLDN6 蛋白
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Claudin 6 (CLDN6) (AA 1-220) (Active) protein-VLP
CLDN6 宿主: Cynomolgus 宿主: HEK-293 Cells VLP > 95 % as determined by HPLC ELISA, Imm, Func, SPR Active
Claudin 6 (CLDN6) (AA 1-220) (Active) protein-VLPCLDN6 宿主: 人 宿主: HEK-293 Cells VLP > 95 % as determined by HPLC. ELISA, Imm, Func, SPR Active
Claudin 6 (CLDN6) (AA 1-219) (Active) protein-VLPCLDN6 宿主: 小鼠 宿主: HEK-293 Cells VLP > 95 % as determined by HPLC ELISA, Imm, Func, SPR Active
Claudin 6 (CLDN6) (AA 1-220) (Active) protein-VLP (Biotin)CLDN6 宿主: 人 宿主: HEK-293 Cells VLP > 95 % as determined by HPLC ELISA, Imm, Func, SPR Active
Claudin 6 (CLDN6) (AA 138-160) protein (Fc Tag)CLDN6 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Claudin 6 (CLDN6) (AA 1-4) protein (mFc Tag)CLDN6 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Claudin 6 (CLDN6) (AA 1-220) protein (GST tag)CLDN6 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Claudin 6 (CLDN6) protein-VLPCLDN6 宿主: 人 宿主: HEK-293 Cells VLP
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- 说明
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Advantages of Membrane Nanoparticles (MNPs):
- High display density of target membrane proteins
- Native structure and orientation of transmembrane protein
- soluble in aqueous solutions for routine biochemical analysis
- Detergent-free purification process
- Strong immunogenicity
- Works for MPs that can´t be produced via VLPs and EXos
- Lack of accurate quantification of the target membrane proteins.
- Need to develop special SPR assayx.
- Cell membranes contain housekeeping proteins that can result in immune response dilution.
- Some membrane proteins can´t be enriched on membrane.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- Claudin 6 (CLDN6)
- 别名
- CLDN6 (CLDN6 产品)
- 别名
- cldn4l2 Protein, cldn6 Protein, CLDN6 Protein, AL024037 Protein, claudin 6, gene 1 L homeolog Protein, claudin 6 Protein, cldn6.1.L Protein, CLDN6 Protein, Cldn6 Protein
- 背景
- Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.
- 分子量
- The human full length CLDN6 Protein has a MW of 23 kDa
- UniProt
- P56747
- 途径
- Hepatitis C
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