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- 抗原 See all CNR1 蛋白
- CNR1 (Cannabinoid Receptor 1 (CNR1))
- 蛋白类型
- MSP Nanodisc
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宿主
- 人
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资源
- Mammalian Cells
- 原理
- Human CB1 full length protein membrane nanoparticles (MNPs)
- 产品特性
- Plasma membrane-coated nanoparticles (MNPs) have been used in various applications, including delivery of therapeutic agents and induction of immune responses et al. Unlike the conventional strategies, MNPs directly leverage intact and natural functions of cell membranes, and show high biocompatibility, specificity, and low side effects. Our optimized MNPs platform for the full-length membrane protein production uses membrane coating technology and a HEK293 based expression platform. The high-purity plasma membrane-coated nanoparticles were produced by extrusion after membrane extraction from the host HEK293 cells containing the overexpressed target proteins.
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Cannabinoid Receptor 1 (CNR1) protein
CNR1 宿主: 人 宿主: HEK-293 Cells Synthetic Nanodisc
Cannabinoid Receptor 1 (CNR1) (AA 1-472) protein (GST tag)CNR1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Cannabinoid Receptor 1 (CNR1) (AA 1-110) protein (GST tag)CNR1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Cannabinoid Receptor 1 (CNR1) (AA 1-116) protein (Fc Tag)CNR1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Cannabinoid Receptor 1 (CNR1) (AA 1-118) protein (Fc Tag)CNR1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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- 说明
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Advantages of Membrane Nanoparticles (MNPs):
- High display density of target membrane proteins
- Native structure and orientation of transmembrane protein
- soluble in aqueous solutions for routine biochemical analysis
- Detergent-free purification process
- Strong immunogenicity
- Works for MPs that can´t be produced via VLPs and EXos
- Lack of accurate quantification of the target membrane proteins.
- Need to develop special SPR assayx.
- Cell membranes contain housekeeping proteins that can result in immune response dilution.
- Some membrane proteins can´t be enriched on membrane.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- CNR1 (Cannabinoid Receptor 1 (CNR1))
- 别名
- CB1 (CNR1 产品)
- 别名
- CANN6 Protein, CB-R Protein, CB1 Protein, CB1A Protein, CB1K5 Protein, CB1R Protein, CNR Protein, SKR6R Protein, cnr1-A Protein, cannabinoid receptor 1 Protein, cannabinoid receptor 1 (brain) Protein, cannabinoid receptor 1 (brain) S homeolog Protein, CNR1 Protein, Cnr1 Protein, cnr1 Protein, cnr1.S Protein
- 背景
- The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.
- 分子量
- The human full length CB1 Protein has a MW of 52.7 kDa
- UniProt
- P21554
- 途径
- Feeding Behaviour
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