-
- 抗原 See all CALCRL 蛋白
- CALCRL (Calcitonin Receptor-Like (CALCRL))
- 蛋白类型
- Synthetic Nanodisc
- 宿主
- 人
-
资源
- Mammalian Cells
- 原理
- Human CGRPR-RAMP1 full length protein-synthetic nanodisc
- 产品特性
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
-
Calcitonin Receptor-Like (CALCRL) (AA 23-132) protein (GST tag)
CALCRL 宿主: 人 宿主: 小麦胚 Recombinant AP, AA, ELISA, WB
Calcitonin Receptor-Like (CALCRL) (AA 23-140) protein (mFc Tag)CALCRL 宿主: 人 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Calcitonin Receptor-Like (CALCRL) (AA 23-140) protein (Fc Tag)CALCRL 宿主: 人 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Calcitonin Receptor-Like (CALCRL) (AA 1-461) protein (GST tag)CALCRL 宿主: 人 宿主: 小麦胚 Recombinant AP, AA, ELISA, WB
Calcitonin Receptor-Like (CALCRL) proteinCALCRL 宿主: 人 宿主: Mammalian Cells MSP Nanodisc
-
- 说明
-
Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 缓冲液
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
-
- 抗原
- CALCRL (Calcitonin Receptor-Like (CALCRL))
- 别名
- CGRPR (CALCRL 产品)
- 别名
- CALCRL Protein, CGRPR Protein, CRLR Protein, AV071593 Protein, CLR Protein, Crlr Protein, RATCRLR Protein, RNCLR Protein, calcitonin receptor like receptor Protein, calcitonin receptor-like Protein, calcitonin receptor like receptor L homeolog Protein, CALCRL Protein, LOC100168906 Protein, calcrl Protein, Calcrl Protein, calcrl.L Protein
- 背景
- The CGRP receptor (CGRPR) is a member of family B G protein coupled receptors (GPCRs), is expressed throughout the trigeminal system, including neurons and endothelial cells. They usually function with accessory proteins such as receptor activity modifying proteins (RAMPs) and Na/H exchange regulatory factors (NHERFs). CGRPR is a heterodimer complex of the calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1). Therapeutics for migraine treatment are mostly targeting CRLR-RAMP1 protein-protein interaction surfaces, thereby blocking CGRP activity.
- 分子量
- The human full length CGRPR protein has a MW of 53.0 kDa
- UniProt
- Q16602
- 途径
- cAMP Metabolic Process
-
You are here:
