ADAM17 Protein (AA 581-642) (mFc Tag)
ADAM17
宿主: 人
宿主: Mammalian Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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- 抗原 See all ADAM17 蛋白
- ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))
- 蛋白类型
- Recombinant
- 产品特性
- AA 581-642
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宿主
- 人
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资源
- Mammalian Cells
- 标记
- This ADAM17 protein is labelled with mFc Tag.
- 原理
- Recombinant human ADAM17(581-642) Protein with C-terminal mouse Fc tag
- 特异性
- ADAM17 (Phe581-Glu642) mFc (Pro99-Lys330)
- 产品特性
- Extracellular Domain Protein
- 纯化方法
- Purified from cell culture supernatant by affinity chromatography
- 纯度
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product ADAM17 蛋白
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ADAM Metallopeptidase Domain 17 (ADAM17) (AA 752-824) protein (His-IF2DI Tag)
ADAM17 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 215-314) protein (GST tag)ADAM17 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))
- 别名
- ADAM17 (ADAM17 产品)
- 别名
- ADAM18 Protein, CD156B Protein, CSVP Protein, NISBD Protein, TACE Protein, CD156b Protein, Tace Protein, adam17 Protein, si:dkey-81b15.2 Protein, adam18 Protein, cd156b Protein, csvp Protein, tace Protein, fc20b01 Protein, wu:fc20b01 Protein, zgc:63886 Protein, ADAM metallopeptidase domain 17 Protein, a disintegrin and metallopeptidase domain 17 Protein, ADAM metallopeptidase domain 17b Protein, ADAM metallopeptidase domain 17 L homeolog Protein, ADAM metallopeptidase domain 17a Protein, ADAM17 Protein, Adam17 Protein, adam17b Protein, adam17.L Protein, adam17a Protein
- 背景
- This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands, and plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. Additionally, this protease may play a role in viral infection through its cleavage of ACE2, the cellular receptor for SARS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2020]
- 分子量
- predicted molecular mass of 33.2 kDa after removal of the signal peptide. The apparent molecular mass of ADAM17(581-642)-mFc is 35-55 kDa due to glycosylation.
- UniProt
- P78536
- 途径
- Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus
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