HTR2C 蛋白
HTR2C
宿主: 人
宿主: Mammalian Cells
Synthetic Nanodisc
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- 抗原 See all HTR2C 蛋白
- HTR2C (5-Hydroxytryptamine (serotonin) Receptor 2C (HTR2C))
- 蛋白类型
- Synthetic Nanodisc
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宿主
- 人
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资源
- Mammalian Cells
- 原理
- Human 5HT2C full length protein-synthetic nanodisc
- 产品特性
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
- Top Product
- Discover our top product HTR2C 蛋白
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5-Hydroxytryptamine (serotonin) Receptor 2C (HTR2C) (AA 1-198) protein (His tag)
HTR2C 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
5-Hydroxytryptamine (serotonin) Receptor 2C (HTR2C) (AA 1-52) protein (GST tag)HTR2C 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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- 说明
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- HTR2C (5-Hydroxytryptamine (serotonin) Receptor 2C (HTR2C))
- 别名
- 5HT2C (HTR2C 产品)
- 别名
- 5-HT2C Protein, 5-HTR2C Protein, HTR1C Protein, 5-HT2cR Protein, 5HT1c Protein, Htr1c Protein, SR1 Protein, 5HT-1C Protein, 5HT2C Protein, 5-HT-2C Protein, 5-ht2cr Protein, si:dkey-24g18.2 Protein, 5ht2c Protein, 5HTR2C Protein, 5-hydroxytryptamine receptor 2C Protein, 5-hydroxytryptamine (serotonin) receptor 2C Protein, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled S homeolog Protein, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 Protein, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Protein, HTR2C Protein, Htr2c Protein, htr2c.S Protein, htr2cl1 Protein, LOC407134 Protein
- 背景
- This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]
- 分子量
- The human full length 5HT2C protein has a MW of 51.8kDa
- UniProt
- P28335
- 途径
- Inositol Metabolic Process, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour
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