HTR2A 蛋白
HTR2A
宿主: 人
宿主: Mammalian Cells
Synthetic Nanodisc
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- 抗原 See all HTR2A 蛋白
- HTR2A (5-Hydroxytryptamine (serotonin) Receptor 2A (HTR2A))
- 蛋白类型
- Synthetic Nanodisc
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宿主
- 人
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资源
- Mammalian Cells
- 原理
- Human 5HT2A full length protein-synthetic nanodisc
- 产品特性
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
- Top Product
- Discover our top product HTR2A 蛋白
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- 说明
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- HTR2A (5-Hydroxytryptamine (serotonin) Receptor 2A (HTR2A))
- 别名
- 5HT2A (HTR2A 产品)
- 别名
- 5-HT2A Protein, HTR2 Protein, 5-HT-2 Protein, 5-HT-2A Protein, 5-HTR2A Protein, LOC100009461 Protein, E030013E04 Protein, Htr-2 Protein, Htr2 Protein, 5Ht-2 Protein, 5HT2A Protein, 5HTR2A Protein, HTR2A Protein, Htr2a Protein, 5HT2 Protein, 5-hydroxytryptamine receptor 2A Protein, 5-hydroxytryptamine (serotonin) receptor 2A Protein, HTR2A Protein, Htr2a Protein
- 背景
- This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
- 分子量
- The human full length 5HT2A protein has a MW of 52.6kDa
- UniProt
- P28223
- 途径
- JAK/STAT Signaling, Inositol Metabolic Process, Regulation of Carbohydrate Metabolic Process
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