ERBB4 Protein (Fc Tag,His tag)
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- 抗原 See all ERBB4 蛋白
- ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This ERBB4 protein is labelled with Fc Tag,His tag.
- 原理
- Active Recombinant Human ErbB-4/HER4 Protein
- 序列
- QSVCAGTENK LSSLSDLEQQ YRALRKYYEN CEVVMGNLEI TSIEHNRDLS FLRSVREVTG YVLVALNQFR YLPLENLRII RGTKLYEDRY ALAIFLNYRK DGNFGLQELG LKNLTEILNG GVYVDQNKFL CYADTIHWQD IVRNPWPSNL TLVSTNGSSG CGRCHKSCTG RCWGPTENHC QTLTRTVCAE QCDGRCYGPY VSDCCHRECA GGCSGPKDTD CFACMNFNDS GACVTQCPQT FVYNPTTFQL EHNFNAKYTY GAFCVKKCPH NFVVDSSSCV RACPSSKMEV EENGIKMCKP CTDICPKACD GIGTGSLMSA QTVDSSNIDK FINCTKINGN LIFLVTGIHG DPYNAIEAID PEKLNVFRTV REITGFLNIQ SWPPNMTDFS VFSNLVTIGG RVLYSGLSLL ILKQQGITSL QFQSLKEISA GNIYITDNSN LCYYHTINWT TLFSTINQRI VIRDNRKAEN CTAEGMVCNH LCSSDGCWGP GPDQCLSCRR FSRGRICIES CNLYDGEFRE FENGSICVEC DPQCEKMEDG LLTCHGPGPD NCTKCSHFKD GPNCVEKCPD GLQGANSFIF KYADPDRECH PCHPNCTQGC NGPTSHDCIY YPWTGHSTLP QHAR
- 特异性
- Gln26-Arg649
- 纯度
- > 97 % by SDS-PAGE.
- 过滤
- 0.22 μm filtered
- 内毒素水平
- < 0.1 EU/μg of the protein by LAL method.
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human NRG1-beta1 at 2 μg/mL (100 μL/well) can bind Recombinant Human HER4/ErbB4, the EC50 of HER4/ErbB4 is 20.99 ng/mL.|2.Measured by its binding ability in a functional ELISA.Immobilized Human ErbB4/Her4 Antibody at 1μg/mL (25 μL/well) can bind Human ErbB4/Her4 with a linear range of 0.46-14.6 ng/mL.
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- Discover our top product ERBB4 蛋白
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V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (AA 26-651) protein (His-Avi Tag)
ERBB4 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (AA 26-651) protein (Fc Tag)ERBB4 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (AA 26-651) protein (His-Avi Tag,Biotin)ERBB4 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (AA 1-1308) protein (GST tag)ERBB4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (AA 26-125) protein (GST tag)ERBB4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (Active) protein (His tag)ERBB4 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (Active) protein (His tag)ERBB4 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (Active) protein (Fc Tag)ERBB4 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (AA 26-651) protein (His tag)ERBB4 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (Active) protein (Myc-DYKDDDDK Tag)ERBB4 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD, Func, PI Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- 缓冲液
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
- 储存条件
- -20 °C,-80 °C
- 储存方法
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Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
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- 抗原
- ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))
- 别名
- ErbB-4/HER4 (ERBB4 产品)
- 别名
- erbb4 Protein, si:ch211-227n20.1 Protein, Her4 Protein, c-erbB-4 Protein, HER4 Protein, p180erbB4 Protein, erb-b2 receptor tyrosine kinase 4 Protein, erb-b2 receptor tyrosine kinase 4a Protein, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) Protein, erb-b2 receptor tyrosine kinase 4 L homeolog Protein, receptor tyrosine-protein kinase ErbB-4 Protein, ERBB4 Protein, erbb4a Protein, erbb4 Protein, erbb4.L Protein, Tsp_13582 Protein, Erbb4 Protein
- 背景
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Description: This protein is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized.
Name: ALS19,HER4,p180erbB4,ERBB4,HER4/ErbB4
- 基因ID
- 2066
- UniProt
- Q15303
- 途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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