IGFBP6 Protein (His tag)
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- 抗原 See all IGFBP6 蛋白
- IGFBP6 (Insulin-Like Growth Factor Binding Protein 6 (IGFBP6))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This IGFBP6 protein is labelled with His tag.
- 原理
- Active Recombinant Human IGFBP-6 Protein
- 序列
- MTPHRLLPPL LLLLALLLAA SPGGALARCP GCGQGVQAGC PGGCVEEEDG GSPAEGCAEA EGCLRREGQE CGVYTPNCAP GLQCHPPKDD EAPLRALLLG RGRCLPARAP AVAEENPKES KPQAGTARPQ DVNRRDQQRN PGTSTTPSQP NSAGVQDTEM GPCRRHLDSV LQQLQTEVYR GAQTLYVPNC DHRGFYRKRQ CRSSQGQRRG PCWCVDRMGK SLPGSPDGNG SSSCPTGSSG
- 特异性
- Met1-Gly240
- 纯度
- > 95 % by SDS-PAGE.
- 过滤
- 0.22 μm filtered
- 内毒素水平
- < 0.1 EU/μg of the protein by LAL method.
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA. Immobilized recombinant human IGFBP6 at 1 μg/mL (100 μL/well) can bind recombinant human IGF1 with a linear range of 30-250 ng/mL.
- Top Product
- Discover our top product IGFBP6 蛋白
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Insulin-Like Growth Factor Binding Protein 6 (IGFBP6) (AA 28-240) protein (His tag)
IGFBP6 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Insulin-Like Growth Factor Binding Protein 6 (IGFBP6) protein (His tag)IGFBP6 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Insulin-Like Growth Factor Binding Protein 6 (IGFBP6) (AA 1-240) protein (GST tag)IGFBP6 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Insulin-Like Growth Factor Binding Protein 6 (IGFBP6) (Active) protein (His tag)IGFBP6 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 92 % as determined by SDS-PAGE Active
Insulin-Like Growth Factor Binding Protein 6 (IGFBP6) protein (His tag)IGFBP6 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- 缓冲液
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
- 储存条件
- -20 °C,-80 °C
- 储存方法
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Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
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- 抗原
- IGFBP6 (Insulin-Like Growth Factor Binding Protein 6 (IGFBP6))
- 别名
- IGFBP-6 (IGFBP6 产品)
- 别名
- IBP6 Protein, IGFBP-6 Protein, IGF-BP6 Protein, RBP6A Protein, IGFBP6 Protein, igfbp6 Protein, insulin like growth factor binding protein 6 Protein, insulin-like growth factor binding protein 6 Protein, IGFBP6 Protein, Igfbp6 Protein, IGFBP-6 Protein, igfbp6 Protein
- 背景
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Description: The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, they can bind IGF-I and IGF-II with the equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have been shown to either inhibit or enhance the action of IGF, or act in an IGF-independent manner in the prostate. IGF-binding protein-4 (IGFBP-4) inhibits IGF-I action in vitro and is the most abundant IGFBP in the rodent arterial wall. IGFBP6 is directly downregulated by the beta-catenin/TCF complex in desmoid tumors, and imply a role for the IGF axis in the proliferation of desmoid tumors. There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence and IGF affinity.
Name: IGFBP6,IBP6
- 基因ID
- 3489
- UniProt
- P24592
- 途径
- WNT signaling, Myometrial Relaxation and Contraction
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