DC-SIGN/CD209 Protein (His tag)
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- 抗原 See all DC-SIGN/CD209 (CD209) 蛋白
- DC-SIGN/CD209 (CD209) (CD209)
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This DC-SIGN/CD209 protein is labelled with His tag.
- 原理
- Active Recombinant Human DC-SIGN/CD209 Protein
- 序列
- QVSKVPSSIS QEQSRQDAIY QNLTQLKAAV GELSEKSKLQ EIYQELTQLK AAVGELPEKS KLQEIYQELT RLKAAVGELP EKSKLQEIYQ ELTWLKAAVG ELPEKSKMQE IYQELTRLKA AVGELPEKSK QQEIYQELTR LKAAVGELPE KSKQQEIYQE LTRLKAAVGE LPEKSKQQEI YQELTQLKAA VERLCHPCPW EWTFFQGNCY FMSNSQRNWH DSITACKEVG AQLVVIKSAE EQNFLQLQSS RSNRFTWMGL SDLNQEGTWQ WVDGSPLLPS FKQYWNRGEP NNVGEEDCAE FSGNGWNDDK CNLAKFWICK KSAASCSRDE EQFLSPAPAT PNPPPA
- 特异性
- Gln59-Ala404
- 纯度
- > 95 % by SDS-PAGE.
- 过滤
- 0.22 μm filtered
- 内毒素水平
- <0.1EU/μg
- Biological Activity Comment
- Measured by the ability of the immobilized protein to support the adhesion of ICAM-3 expressing CHO Chinese hamster ovary cells. When 5 x 104 cells/well are added to Recombinant Human DC_x001e_SIGN/CD209 Protein coated plates (5 μg/mL with 100 μL/well), approximately 10-20% of added cells will adhere after 1 hour at 37°C.
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- Discover our top product CD209 蛋白
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CD209 (CD209) (AA 59-404) protein (His tag)
CD209 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD209 (CD209) protein (Fc Tag)CD209 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
CD209 (CD209) (AA 1-404) protein (GST tag)CD209 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
CD209 (CD209) (AA 271-380) protein (GST tag)CD209 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
CD209 (CD209) (AA 70-404) protein (T7 tag,His tag)CD209 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant ≥ 94 % ELISA, WB, SDS, IP
CD209 (CD209) (AA 115-238) protein (T7 tag,His tag)CD209 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant ≥ 96 % ELISA, WB, SDS, IP
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- 缓冲液
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
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- 抗原
- DC-SIGN/CD209 (CD209) (CD209)
- 别名
- DC-SIGN/CD209 (CD209 产品)
- 别名
- CDSIGN Protein, CLEC4L Protein, DC-SIGN Protein, DC-SIGN1 Protein, cd209 Protein, CLEC4M Protein, si:ch211-224h1.3 Protein, CD209 Protein, CIRE Protein, Dcsign Protein, SIGN-R1 Protein, SIGNR5 Protein, Cd209 Protein, CD209 molecule Protein, CD209a antigen Protein, CD209 antigen-like protein D Protein, CD209c molecule Protein, CD209 antigen Protein, CD209 Protein, cd209 Protein, Cd209a Protein, LOC100529184 Protein, Cd209c Protein, LOC100460708 Protein, LOC105484282 Protein
- 背景
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Description: Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin (DC-SIGN), also known as CD209, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has an important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. DC-SIGN also mediates the capture and internalization of viral, bacterial, and fungal pathogens by dendritic cells, such as HIV-1, Ebola virus, cytomegalovirus, Dengue virus, and hepatitis C virus. DC-SIGN is unique in that it regulates adhesion processes, such as DC trafficking and T-cell synapse formation, as well as antigen capture. Moreover, even though several C-type lectins have been shown to bind HIV-1, DC-SIGN does not only capture HIV-1 but also protects it in early endosomes allowing HIV-1 transport by DC to lymphoid tissues, where it enhances trans infection of T cells.
Name: CD209,CDSIGN,CLEC4L,DC-SIGN,DC-SIGN1, CLEC4L, DC-SIGN, DC-SIGN1
- 基因ID
- 30835
- UniProt
- Q9NNX6-1
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