PLAT Protein (AA 309-559) (His tag)
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- 抗原 See all PLAT 蛋白
- PLAT (Plasminogen Activator, Tissue (PLAT))
- 蛋白类型
- Recombinant
- 产品特性
- AA 309-559
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This PLAT protein is labelled with His tag.
- 序列
- Ile309-Gln559
- 产品特性
- A DNA sequence encoding the Mouse tPA protein (P11214) (309-559) was expressed with a C-His.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product PLAT 蛋白
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Plasminogen Activator, Tissue (PLAT) (AA 36-562) protein (His tag)
PLAT 宿主: 人 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Plasminogen Activator, Tissue (PLAT) (AA 1-562) protein (GST tag)PLAT 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- PLAT (Plasminogen Activator, Tissue (PLAT))
- 别名
- tPA (PLAT 产品)
- 别名
- T-PA Protein, TPA Protein, AU020998 Protein, AW212668 Protein, D8Ertd2e Protein, tPA Protein, PATISS Protein, tpa Protein, Plat Protein, plat Protein, t-pa Protein, plasminogen activator, tissue type Protein, plasminogen activator, tissue Protein, chromosome 20 open reading frame 181 Protein, plasminogen activator, tissue L homeolog Protein, PLAT Protein, Plat Protein, plat Protein, C20orf181 Protein, plat.L Protein
- 背景
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Abbreviation: tPA;PLAT
Target Synonym: Tissue-type plasminogen activator;t-PA;t-plasminogen activator;tPA;EC 3.4.21.68;Plat
Background: Tissue plasminogen activator (abbreviated tPA or PLAT), is traditionally viewed as a simple serine protease whose main function is to convert plasminogen into biologically active plasmin. As a protease, tPA plays a crucial role in regulating blood fibrinolysis, in maintaining the homeostasis of extracellular matrix and in modulating the post-translational activation of growth factors. tPA is synthesized and secreted as a single chain polypeptide precursor which is cleaved in turn by plasmin. Proteolytic cleavage at the C-terminal side of Arg275 generates the enzyme composed of two subunits, designated as α and β chains which are held together by a single disulfide bond. Unlike the other members of the chymotrypsin family, tPA has one particular distinction in that the catalytic efficiency of the single-chain enzyme is only slightly lower than that of the proteolytically cleaved form and is therefore not a true zymogen. tPA is found not only in the blood, where its primary function is as a thrombolytic enzyme, but also in the central nervous system (CNS). It participats in a number of physiological and pathological events in the CNS, as well as the role of neuroserpin as the natural regulator of tPA's activity in these processes. Increased or decreased activity of tPA leads to hyperfibrinolysis or hypofibrinolysis, respectively. In addition, as a cytokine, tPA plays a pivotal role in the pathogenesis of renal interstitial fibrosis through diverse mechanisms. Thus, as a fibrogenic cytokine, it promotes the progression of kidney diseases.
- 分子量
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Calculated MW: 27.5 kDa
Observed MW: 38 kDa
- UniProt
- P11214
- 途径
- Autophagy, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, SARS-CoV-2 Protein Interactome
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