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LDLR Protein (AA 1-790) (His tag)

LDLR 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7505737
发货至: 中国
  • 抗原 See all LDLR 蛋白
    LDLR (Low Density Lipoprotein Receptor (LDLR))
    蛋白类型
    Recombinant
    产品特性
    AA 1-790
    宿主
    • 19
    • 9
    • 3
    • 2
    • 1
    小鼠
    资源
    • 19
    • 6
    • 4
    • 2
    • 2
    • 1
    HEK-293 Cells
    标记
    This LDLR protein is labelled with His tag.
    序列
    Met 1-Arg 790
    产品特性
    A DNA sequence encoding the Mouse LDLR protein (P35951) (Met 1-Arg 790) was expressed with a C-His.
    纯度
    > 95 % as determined by reducing SDS-PAGE.
    Top Product
    Discover our top product LDLR 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    Lyophilized from sterile PBS, pH 7.4.
    Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    有效期
    12 months
  • 抗原
    LDLR (Low Density Lipoprotein Receptor (LDLR))
    别名
    LDLR (LDLR 产品)
    别名
    FH Protein, FHC Protein, LDLCQ2 Protein, Hlb301 Protein, LDLRA Protein, LDLA Protein, LDL receptor-2 Protein, fhc Protein, ldlcq2 Protein, ldlr Protein, ldlr2-a Protein, LDL receptor 1 Protein, ldlr-a Protein, ldlr-b Protein, low density lipoprotein receptor Protein, low density lipoprotein receptor a Protein, low density lipoprotein receptor S homeolog Protein, low density lipoprotein receptor L homeolog Protein, LDLR Protein, Ldlr Protein, ldlra Protein, ldlr.S Protein, ldlr.L Protein
    背景

    Abbreviation: LDLR

    Target Synonym: Low-density lipoprotein receptor,LDL receptor,Ldlr

    Background: LDL Receptor, also known as LDLR, is a mosaic protein which belongs to the Low density lipoprotein receptor gene family. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL Receptor consists of 840 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. LDL Receptor is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants.

    分子量

    Calculated MW: 86.79 kDa

    Observed MW: 90 kDa

    UniProt
    P35951
    途径
    Hepatitis C, Lipid Metabolism
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