IL1RN Protein (AA 27-178) (His tag)
-
- 抗原 See all IL1RN 蛋白
- IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))
- 蛋白类型
- Recombinant
- 产品特性
- AA 27-178
-
宿主
- 小鼠
-
资源
- HEK-293 Cells
- 标记
- This IL1RN protein is labelled with His tag.
- 序列
- Arg27-Gln178
- 产品特性
- A DNA sequence encoding the Mouse IL-1ra/IL-1F3 protein (P25085) (Arg27-Gln178) was expressed with a C-His.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product IL1RN 蛋白
-
Interleukin 1 Receptor Antagonist (IL1RN) (AA 1-159) protein (GST tag)
IL1RN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Interleukin 1 Receptor Antagonist (IL1RN) (AA 25-178) protein (His tag)IL1RN 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Interleukin 1 Receptor Antagonist (IL1RN) (AA 18-332) protein (Fc Tag)IL1RN 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 1 Receptor Antagonist (IL1RN) proteinIL1RN 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 缓冲液
-
Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
-
- 抗原
- IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))
- 别名
- IL-1ra (IL1RN 产品)
- 别名
- DIRA Protein, ICIL-1RA Protein, IL-1RN Protein, IL-1ra Protein, IL-1ra3 Protein, IL1F3 Protein, IL1RA Protein, IRAP Protein, MVCD4 Protein, IRAP1 Protein, IL1RN Protein, IL-1RA Protein, F630041P17Rik Protein, interleukin 1 receptor antagonist Protein, interleukin 1 receptor antagonist-like Protein, IL1RN Protein, Il1rn Protein, IL1RNL Protein
- 背景
-
Abbreviation: IL-1ra,IL-1F3
Target Synonym: IL-1RN,IL-1ra,IRAP,IL1 inhibitor,Il1rn,Interleukin-1 Receptor Antagonist Protein
Background: Interleukin-1 receptor antagonist protein (Il1rn), also known as IL-1ra, IRAP or IL1 inhibitor, is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1 alpha (IL1A) and interleukin 1 beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. The mouse Il1rn gene encodes a 178 amino acids (aa) protein with a 26 aa signal peptide. Mouse Il1rn protein shares 26 % and 19 % identity with its homologues IL-1 beta and IL-1 alpha, respectively. Il1rn can Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling, but has no interleukin-1 like activity. Recently, an recombinant human Il1rn protein is used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role.
- 分子量
-
Calculated MW: 16.61 kDa
Observed MW: 22 kDa
- UniProt
- P25085
- 途径
- NF-kappaB Signaling, Hormone Transport, Cancer Immune Checkpoints
-
