Cathepsin S Protein (CTSS) (AA 1-331) (His tag)
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- 抗原 See all Cathepsin S (CTSS) 蛋白
- Cathepsin S (CTSS)
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-331
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Cathepsin S protein is labelled with His tag.
- 序列
- Met 1-Ile 331
- 产品特性
- A DNA sequence encoding the Human CTSS protein (P25774) (Met 1-Ile 331) was expressed with a C-His.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CTSS 蛋白
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Cathepsin S (CTSS) (AA 1-331) protein (GST tag)
CTSS 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cathepsin S (CTSS) protein (His tag)CTSS 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Cathepsin S (CTSS) (Active) protein (His tag)CTSS 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- Cathepsin S (CTSS)
- 别名
- Cathepsin S (CTSS 产品)
- 别名
- ctss-a Protein, MGC69026 Protein, ctss-b Protein, MGC80097 Protein, ctss.1 Protein, CTSS Protein, ctss Protein, cats Protein, cathepsin S Protein, cathepsin S L homeolog Protein, cathepsin S S homeolog Protein, Cathepsin S Protein, CTSS Protein, Ctss Protein, ctss.L Protein, ctss.S Protein, ctss Protein, cats Protein
- 背景
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Abbreviation: Cathepsin S,CTSS
Target Synonym: Cathepsin S,CTSS,CTSS,MGC3886
Background: Cathepsin S (CTSS), one of the lysosomal proteinases, has many important physiological functions in the nervous system, especially in process of extracellular matrix degradation and endocellular antigen presentation. CTSS is synthesized as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide, a propeptide of 99 aa, and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. Cathepsin S is expressed in the lysosome of antigen presenting cells, primarily dendritic cells, B-cells and macrophages. Compared with other lysosomal cysteine proteases, cathepsin S has displayed some unique characteristics. Cathepsin S is most well known for its critical function in the proteolytic digestion of the invariant chain chaperone molecules, thus controlling antigen presentation to CD4+ T-cells by major histocompatibility complex (MHC) class II molecules or to NK1.1+ T-cells via CD1 Molecules. Cathepsin S also appears to participate in direct processing of exogenous antigens for presentation by MHC class II to CD4+ T-cells, or in cross-presentation by MHC class I molecules to CD8+ T-cells. In addition, although direct evidence is still lacking, in its secreted form cathepsin S is implicated in degradation of the extracellular matrix, which may contribute to the pathology of a number of diseases, including arthritis, atherosclerosis, neurological diseases and chronic obstructive pulmonary disease.
- 分子量
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Calculated MW: 36.3 kDa
Observed MW: 38 kDa
- UniProt
- P25774
- 途径
- Activation of Innate immune Response, Toll-Like Receptors Cascades
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