RAGE Protein (AA 1-342) (His tag)
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- 抗原 See all RAGE (AGER) 蛋白
- RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-342
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This RAGE protein is labelled with His tag.
- 序列
- Met1-Ala342
- 产品特性
- A DNA sequence encoding the Human AGER protein (Q15109) (Met1-Ala342) was expressed with a C-His.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product AGER 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
- 别名
- AGER (AGER 产品)
- 别名
- RAGE Protein, AGER Protein, advanced glycosylation end-product specific receptor Protein, advanced glycosylation end product-specific receptor Protein, MAPK/MAK/MRK overlapping kinase Protein, AGER Protein, Ager Protein, LOC719012 Protein
- 背景
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Abbreviation: AGER
Target Synonym: Advanced Glycosylation End Product-Specific Receptor,Receptor for Advanced Glycosylation End Products,AGER,RAGE
Background: Advanced Glycosylation End Product-Specific Receptor (AGER) belongs to the immunoglobulin superfamily of cell surface molecules. It lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Besides AGEs, AGER is also able to bind other ligands which is thought to result in pro-inflammatory gene activation. It is known that AGER serve as a mediator of both acute and chronic vascular inflammation in certain conditions such as atherosclerosis and in particular as a complication of diabetes. Furthermore, it plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.
- 分子量
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Calculated MW: 37.51 kDa
Observed MW: 45 kDa
- UniProt
- Q15109
- 途径
- Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins
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