Granulin Protein (GRN) (AA 1-593) (His tag)
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- 抗原 See all Granulin (GRN) 蛋白
- Granulin (GRN)
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-593
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Granulin protein is labelled with His tag.
- 序列
- Met1-Leu593
- 产品特性
- A DNA sequence encoding the Human PGRN protein (P28799) (Met1-Leu593) was expressed with a C-His.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
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- Discover our top product GRN 蛋白
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Granulin (GRN) (AA 494-593) protein (GST tag)
GRN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Granulin (GRN) (AA 364-430) protein (His tag)GRN 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Granulin (GRN) (AA 289-426) protein (His-IF2DI Tag)GRN 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Granulin (GRN) (AA 1-593) protein (GST tag)GRN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Granulin (GRN) protein (His tag)GRN 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- Granulin (GRN)
- 别名
- Granulin (GRN 产品)
- 别名
- GRN Protein, grn Protein, wu:fb11g12 Protein, wu:fj18f05 Protein, MGC53354 Protein, DKFZp459H066 Protein, CLN11 Protein, GEP Protein, GP88 Protein, PCDGF Protein, PEPI Protein, PGRN Protein, epithelin Protein, acrogranin Protein, granulin precursor Protein, granulin a Protein, Granulins Protein, granulin L homeolog Protein, granulin Protein, GRN Protein, grna Protein, grn Protein, grn.L Protein, granulin Protein, ORF1 granulin Protein, Grn Protein
- 背景
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Abbreviation: Granulin,PGRN
Target Synonym: CLN11,GEP,GP88,Granulin,PCDGF,PEPI,PGRN,Progranulin
Background: Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Granulin expression inhibited Tat transactivation, and tethering experiments showed that this effect was due, at least in part, to a direct action on cyclin T1 in the absence of Tat.
- 分子量
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Calculated MW: 65.12 kDa
Observed MW: 80 kDa
- UniProt
- P28799
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