Chromogranin A Protein (CHGA) (AA 1-457) (His tag)
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- 抗原 See all Chromogranin A (CHGA) 蛋白
- Chromogranin A (CHGA)
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-457
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Chromogranin A protein is labelled with His tag.
- 序列
- Met1-Gly457
- 产品特性
- A DNA sequence encoding the Human CHGA protein (P10645) (Met1-Gly457) was expressed with a C-His.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CHGA 蛋白
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Chromogranin A (CHGA) (AA 165-435) protein (His tag)
CHGA 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Chromogranin A (CHGA) (AA 1-457) protein (GST tag)CHGA 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Chromogranin A (CHGA) (AA 338-432) protein (GST tag)CHGA 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Chromogranin A (CHGA) (AA 19-457) protein (His tag)CHGA 宿主: 人 宿主: 酵母菌 Recombinant > 90 % SDS
Chromogranin A (CHGA) (AA 19-457) protein (His tag)CHGA 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 85 % by SDS - PAGE SDS
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- Chromogranin A (CHGA)
- 别名
- CHGA (CHGA 产品)
- 别名
- CGA Protein, CG-ALPHA Protein, FSHA Protein, GPHA1 Protein, GPHa Protein, HCG Protein, LHA Protein, TSHA Protein, ChrA Protein, fj05f09 Protein, si:dkey-177p2.2 Protein, wu:fj05f09 Protein, zgc:101749 Protein, zgc:56075 Protein, CHGA Protein, cgA Protein, chga Protein, chromogranin A Protein, glycoprotein hormones, alpha polypeptide Protein, uncharacterized CHGA Protein, chromogranin A S homeolog Protein, CHGA Protein, CGA Protein, Chga Protein, chga Protein, chga.S Protein
- 背景
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Abbreviation: CHGA
Target Synonym: Chromogranin-A,CgA,Pituitary secretory protein I,SP-I,CHGA
Background: Chromogranin A (CgA), also known as pituitary secretory protein I (SP-I), is a member of the granin family of regulated secretory proteins. CgA shares several protein characteristics common to the granin family: acidic isoelectric point, the capacity to bind calcium ions, the ability to form aggregates and multiple dibasic cleavage sites. Mature human CgA is 439 amino acids (aa) and contains 10 dibasic, proteolytic cleavage sites, capable of yielding several smaller peptides, each displaying a unique function. Mature human CgA shares 63 % aa sequence identity with mouse and rat CgA. CgA is expressed exclusively in the secretory dense core granules of most normal and neoplastic neuroendocrine cells. Increased levels of CgA have been detected inpatients with neuroendocrine tumors as well as non-neuroendocrine tumors, hence CgA is an important serological marker for tumor diagnosis and monitoring tumorprogression/regression. It has been demonstrated in mouse model that full-length CgA containing its C-terminal region can impair angiogenesis and tumor growth. In addition, CgA can bind to Secretogranin III to regulate the biogenesis of secretory granules.
- 分子量
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Calculated MW: 50.16 kDa
Observed MW: 75 kDa
- UniProt
- P10645
- 途径
- Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling
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