TFF3 Protein (AA 1-80) (His tag)
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- 抗原 See all TFF3 蛋白
- TFF3 (Trefoil Factor 3 (Intestinal) (TFF3))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-80
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This TFF3 protein is labelled with His tag.
- 序列
- Met1-Phe80
- 产品特性
- A DNA sequence encoding the Human TFF3 protein (Q07654) (Met1-Phe80) was expressed with a C-His.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product TFF3 蛋白
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Trefoil Factor 3 (Intestinal) (TFF3) (AA 15-73) protein (GST tag)
TFF3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Trefoil Factor 3 (Intestinal) (TFF3) (Active) proteinTFF3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Trefoil Factor 3 (Intestinal) (TFF3) (AA 23-81) protein (His-IF2DI Tag)TFF3 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- TFF3 (Trefoil Factor 3 (Intestinal) (TFF3))
- 别名
- TFF3 (TFF3 产品)
- 别名
- TFF3 Protein, ITF Protein, P1B Protein, TFI Protein, mITF Protein, trefoil factor 3 Protein, trefoil factor 3, intestinal Protein, TFF3 Protein, Tff3 Protein
- 背景
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Abbreviation: TFF3
Target Synonym: Trefoil factor 3,Intestinal trefoil factor,hITF,Polypeptide P1.B,hP1.B,TFF3,ITF,TFI
Background: Trefoil Factor 3 (TFF3), also known as Intestinal Trefoil Factor (ITF) and P1.B, is one of three structurally related secreted proteins that contain trefoil domains. These domains adopt a three-leaved conformation held together by conserved intrachain disulfide bonds. TFF3 is an approximately 7 kDa peptide that plays an important role in epithelial regeneration and wound healing. It can form disulfide-linked dimers or associate into disulfide-linked complexes with the intestinal mucous proteins FCGBP and MUC-2. TFF3 is expressed by epithelial goblet cells in the respiratory tract, biliary and breast ducts, small and large intestine, and cardia of the stomach. Following secretion, TFF3 can be retained in the overlying mucous layer. TFF3 is also expressed by chondrocytes during bone development. Mature human TFF3 shares 76 % amino acid sequence identity with mouse and rat TFF3. TFF3 is up-regulated in response to a range of gastrointestinal epithelial disruptions. It promotes epithelial wound healing by inducing the migration of biliary, bronchial, and intestinal epithelial cells. TFF3 up-regulation is associated with and enhances tumor cell invasion and metastasis. It supports hypoxia-induced VEGF up-regulation in tumor cells and also promotes angiogenesis in non-tumor environments. Over-expression of TFF3 in type 2 diabetic mouse liver has been shown to improve glucose tolerance and insulin sensitivity.
- 分子量
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Calculated MW: 8.69 kDa
Observed MW: 12 kDa
- UniProt
- Q07654
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