F13B Protein (AA 1-661) (His tag)
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- 抗原 See all F13B 蛋白
- F13B (Coagulation Factor 13, B Polypeptide (F13B))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-661
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This F13B protein is labelled with His tag.
- 序列
- Met1-Thr661
- 产品特性
- A DNA sequence encoding the Human F13B protein (P05160) (Met1-Thr661) was expressed with a C-His.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- F13B (Coagulation Factor 13, B Polypeptide (F13B))
- 别名
- Coagulation Factor XIII B chain (F13B 产品)
- 别名
- F13B Protein, coagulation factor XIII B chain Protein, LOC100347263 Protein
- 背景
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Abbreviation: F13B
Target Synonym: Coagulation factor 13,Coagulation factor XIII,FXIIIB
Background: Coagulation factor XIII B chain, also known as Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain and F13B, is a secreted protein which contains 10 Sushi ( CCP / SCR ) domains. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. Factor XIII acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits, and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. Defects in F13B are the cause of factor XIII subunit B deficiency ( FA13BD ) which is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.
- 分子量
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Calculated MW: 72.6 kDa
Observed MW: 80 kDa
- UniProt
- P05160
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