IL7R Protein (AA 21-457) (His tag)
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- 抗原 See all IL7R 蛋白
- IL7R (Interleukin 7 Receptor (IL7R))
- 蛋白类型
- Recombinant
- 产品特性
- AA 21-457
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宿主
- 大鼠
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资源
- 大肠杆菌（E. Coli）
- 标记
- This IL7R protein is labelled with His tag.
- 序列
- Glu 21-Lys 457
- 产品特性
- A DNA sequence encoding the rat IL7R/IL-7R/CD127 protein (D4A3X8) (Glu 21-Lys 457) was expressed with N-His tag.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product IL7R 蛋白
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Interleukin 7 Receptor (IL7R) protein (Fc Tag)
IL7R 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Interleukin 7 Receptor (IL7R) (AA 21-239) protein (Fc Tag)IL7R 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 7 Receptor (IL7R) protein (His tag)IL7R 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Interleukin 7 Receptor (IL7R) (AA 21-236) (Active) protein (Fc Tag)IL7R 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 7 Receptor (IL7R) (Active) protein (Fc Tag)IL7R 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE Active
Interleukin 7 Receptor (IL7R) (Active) protein (Fc Tag)IL7R 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Interleukin 7 Receptor (IL7R) (AA 1-459) protein (GST tag)IL7R 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Interleukin 7 Receptor (IL7R) protein (His tag)IL7R 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- IL7R (Interleukin 7 Receptor (IL7R))
- 别名
- IL7R (IL7R 产品)
- 别名
- IL7R Protein, CD127 Protein, IL-7Ralpha Protein, CDW127 Protein, IL-7R-alpha Protein, IL7RA Protein, ILRA Protein, IL-7RA Protein, interleukin 7 receptor Protein, IL7R Protein, Il7r Protein
- 背景
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Abbreviation: IL7R,IL-7R,CD127
Target Synonym: Interleukin-7 receptor subunit alpha, Il7r,
Background: Interleukin 7 Receptor alpha (IL-7RA), also known as CD127, is a 75 kDa hematopoietin receptor superfamily member that plays an important role in lymphocyte differentiation, proliferation, and survival. IL-7RA signaling is essential for T-cell development and regulation of naive and memory T-cell homeostasis. Studies from both pathogenic and controlled HIV infection indicate that the containment of immune activation and preservation of CD127 expression are critical to the stability of CD4(+) T cells in infection. A better understanding of the factors regulating CD127 expression in HIV disease, particularly on T(CM) cells, might unveil new approaches exploiting the IL-7/IL-7R receptor pathway to restore T cell homeostasis and promote immune reconstitution in HIV infection. Factors relevant to HIV infection that could potentially decrease CD127 expression on human CD8(+) T cells. CD127 down-regulation may be an important contributor to HIV-associated T-cell dysfunction. In addition to IL-7, IL-7RA also associates with TSLPR to form the functional receptor for thymic stromal lymphopoietin (TSLP) which indirectly regulates T cell development by modulating dendritic cell activation. Mutations in the human IL-7RA gene cause a type of severe combined immunodeficiency in which the major deficiencies are in T cell development, whereas B and NK cells are relatively normal in number. Soluble CD127 (sCD127) appears to play an important role in the immunopathogenesis of several chronic infections, multiple sclerosis, and various cancers.
- 分子量
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Calculated MW: 47.96 kDa
Observed MW: 50 kDa
- UniProt
- D4A3X8
- 途径
- JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size
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