IL-10 Protein (AA 19-178) (His tag)
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- 抗原 See all IL-10 (IL10) 蛋白
- IL-10 (IL10) (Interleukin 10 (IL10))
- 蛋白类型
- Recombinant
- 产品特性
- AA 19-178
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宿主
- 大鼠
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资源
- 大肠杆菌（E. Coli）
- 标记
- This IL-10 protein is labelled with His tag.
- 序列
- Ser19-Asn178
- 产品特性
- A DNA sequence encoding the Rat IL10 protein (P29456-1 ) (Ser19-Asn178) was expressed with a N-HIS.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product IL10 蛋白
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Interleukin 10 (IL10) (AA 19-178) protein
IL10 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 10 (IL10) protein (His-Avi Tag)IL10 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Interleukin 10 (IL10) protein (His-Avi Tag,Biotin)IL10 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Interleukin 10 (IL10) (AA 19-178) (Active) proteinIL10 宿主: 人 宿主: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE and HPLC. Active
Interleukin 10 (IL10) (Active) proteinIL10 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Interleukin 10 (IL10) (AA 22-178) protein (His tag)IL10 宿主: Hamster 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Interleukin 10 (IL10) (AA 74-178) protein (GST tag)IL10 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Interleukin 10 (IL10) (AA 1-178) protein (GST tag)IL10 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Interleukin 10 (IL10) (AA 19-178) protein (His tag)IL10 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 10 (IL10) proteinIL10 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- IL-10 (IL10) (Interleukin 10 (IL10))
- 别名
- IL10 (IL10 产品)
- 别名
- CSIF Protein, GVHDS Protein, IL-10 Protein, IL10A Protein, TGIF Protein, Il-10 Protein, IL10X Protein, interleukin 10 Protein, IL10 Protein, Il10 Protein
- 背景
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Abbreviation: IL10
Target Synonym: Interleukin-10,IL-10,Cytokine synthesis inhibitory factor,CSIF,Il10,Il-10
Background: IL-10 is a anti-inflammatory cytokine which belongs to the IL-10 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types, while it is produced primarily by monocytes and to a lesser extent by lymphocytes. IL-10 is mainly expressed in monocytes and Type 2 T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and also in a certain subset of activated T cells and B cells. IL-10 has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. The importance of interleukin 10 for counteracting excessive immunity in the human body is revealed by the fact that patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant IL-10. IL-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production.
- 分子量
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Calculated MW: 17.49 kDa
Observed MW: 15 kDa
- UniProt
- P29456
- 途径
- Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location, Cancer Immune Checkpoints
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