E-cadherin Protein (AA 157-709) (His tag)
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- 抗原 See all E-cadherin (CDH1) 蛋白
- E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
- 蛋白类型
- Recombinant
- 产品特性
- AA 157-709
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宿主
- 小鼠
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资源
- 大肠杆菌（E. Coli）
- 标记
- This E-cadherin protein is labelled with His tag.
- 序列
- Asp 157-Val 709
- 产品特性
- A DNA sequence encoding the Mouse E-Cad protein (P09803) (Asp 157-Val 709) was expressed with a N-His tag.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CDH1 蛋白
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Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (AA 1-882) protein (GST tag)
CDH1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (AA 381-480) protein (GST tag)CDH1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (AA 155-707) protein (His tag)CDH1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) protein (Fc Tag)CDH1 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 75 % as determined by SDS-PAGE
Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (Active) protein (His tag)CDH1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE Active
Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (AA 23-621) (Active) protein (Fc Tag)CDH1 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
- 别名
- E-Cad (CDH1 产品)
- 别名
- Arc-1 Protein, CD324 Protein, CDHE Protein, ECAD Protein, LCAM Protein, UVO Protein, E-cadherin Protein, cdh1 Protein, si:dz180o5.2 Protein, uvo Protein, lcam Protein, E-Cad Protein, XBcad Protein, l-cam Protein, xcdh1 Protein, cdhc-A Protein, xb-cad Protein, XTCAD-1 Protein, c-cadherin Protein, cadherin-1 Protein, uvomorulin Protein, XB-cadherin Protein, arc-1 Protein, cd324 Protein, cdhe Protein, ecad Protein, AA960649 Protein, E-cad Protein, Ecad Protein, L-CAM Protein, Um Protein, cadherin 1 Protein, si:busm1-180o5.2 Protein, cadherin 1, type 1, E-cadherin (epithelial) Protein, cadherin 1, type 1 S homeolog Protein, CDH1 Protein, si:busm1-180o5.2 Protein, cdh1 Protein, Cdh1 Protein, cdh1.S Protein
- 背景
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Abbreviation: E-Cad
Target Synonym: AA960649,ARC-1,E-cad,Ecad,L-CAM,Um,UVO
Background: Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is a calcium-dependent cell adhesion molecule the intact function of which is crucial for the establishment and maintenance of epithelial tissue polarity and structural integrity. Mutations in CDH1 occur in diffuse type gastric cancer, lobular breast cancer, and endometrial cancer. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas.
- 分子量
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Calculated MW: 60.72 kDa
Observed MW: 75 kDa
- UniProt
- P09803
- 途径
- WNT signaling, Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation
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