GDF11 Protein (AA 136-384) (His tag)
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- 抗原 See all GDF11 蛋白
- GDF11 (Growth Differentiation Factor 11 (GDF11))
- 蛋白类型
- Recombinant
- 产品特性
- AA 136-384
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宿主
- 小鼠
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资源
- 大肠杆菌（E. Coli）
- 标记
- This GDF11 protein is labelled with His tag.
- 序列
- Thr 136-Asn 384
- 产品特性
- A DNA sequence encoding the Mouse GDF11 protein (Q9Z1W4) (Thr136~Asn384) was expressed with a N-His .
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product GDF11 蛋白
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Growth Differentiation Factor 11 (GDF11) (AA 310-407) protein (GST tag)
GDF11 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- GDF11 (Growth Differentiation Factor 11 (GDF11))
- 别名
- GDF11 (GDF11 产品)
- 别名
- BMP-11 Protein, BMP11 Protein, Bmp11 Protein, GDF11 Protein, growth differentiation factor 11 Protein, GDF11 Protein, Gdf11 Protein, gdf11 Protein
- 背景
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Abbreviation: GDF11,BMP-11
Target Synonym: Growth/differentiation factor 11,GDF-11,Bone morphogenetic protein 11,BMP-11
Background: Growth Differentiation Factor 11 (GDF-11), also known as BMP-11, is a member of the TGF-beta superfamily and is highly related to GDF-8. GDF-11 encodes a 407 amino acid (aa) prepropeptide which contains a signal sequence for secretion and an RXXR proteolytic processing site to yield a 109 aa residue carboxy-terminal mature protein. Mature GDF-11 contains the canonical 7-cysteine motif common to other TGF-beta superfamily members, however, like the TGF-beta s, Activins and GDF-8, GDF-11 also contains one extra pair of cysteine residues. At the amino acid sequence level, mature human, mouse, rat and chicken GDF-11 are 99-100 % identical. As detected by in situ hybridization, GDF-11 is expressed in diverse regions of the mouse embryo: tailbud, somitic precursors, limbs, mandibular and branchial arches, dorsal neural tube, odontoblasts, nasal epithelium, and particular regions of the brain. Targeted deletion of GDF-11, in mice, results in a spectrum of abnormalities including palatal malformation, vertebral defects, elongated trunks with a reduced or absent tail, missing or malformed kidneys, and an increased number of neurons in the olfactory epithelium. GDF-11 signals through the Activin type II receptors and induces phosphorylation of Smad2 to mediate axial patterning. Systemic GDF-11 levels decline with age and administration of higher levels of GDF-11 can reverse age-related cardiac hypertrophy. In addition, systemic administration of recombinant GDF-11 protein restores genomic integrity and health of muscle stem cells, neurovasculature and enhances neurogenesis.
- 分子量
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Calculated MW: 27.28 kDa
Observed MW: 35 kDa
- UniProt
- Q9Z1W4
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