Caspase 8 Protein (CASP8) (AA 219-376) (His tag)
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- 抗原 See all Caspase 8 (CASP8) 蛋白
- Caspase 8 (CASP8)
- 蛋白类型
- Recombinant
- 产品特性
- AA 219-376
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宿主
- 小鼠
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资源
- 大肠杆菌（E. Coli）
- 标记
- This Caspase 8 protein is labelled with His tag.
- 序列
- Ser 219-Gly 376
- 产品特性
- A DNA sequence encoding the Mouse CASP8 protein (O89110) (Ser219-Gly376) was expressed with a N-His .
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
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- Discover our top product CASP8 蛋白
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Caspase 8 (CASP8) (AA 217-374) protein (His tag)
CASP8 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Caspase 8 (CASP8) (AA 200-496) protein (His tag)CASP8 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Caspase 8 (CASP8) (AA 217-479) protein (His tag)CASP8 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Caspase 8 (CASP8) proteinCASP8 宿主: Cow 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % WB, SDS, ELISA, IP
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- Caspase 8 (CASP8)
- 别名
- Caspase-8 (CASP8 产品)
- 别名
- casp8-A Protein, xCaspase-8 Protein, casp8 Protein, CASP8 Protein, CASP-8 Protein, FLICE Protein, MACH Protein, Mch5 Protein, ALPS2B Protein, CAP4 Protein, Casp-8 Protein, MCH5 Protein, caspase-8 Protein, zgc:92075 Protein, caspase 8 L homeolog Protein, death related ced-3/Nedd2-like protein Protein, caspase 8 Protein, caspase-8 Protein, caspase-8-like Protein, caspase 8, apoptosis-related cysteine peptidase Protein, casp8.L Protein, LOC661095 Protein, CASP8 Protein, LOC5563818 Protein, casp8 Protein, LOC100222284 Protein, Casp8 Protein
- 背景
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Abbreviation: Caspase-8,CASP8
Target Synonym: CASP8_MOUSE,Caspase-8,Casp8,EC:3.4.22.61
Background: Caspase-8 (Cysteine-aspartic acid protease 8/Casp8a, also named MCH5, FLICA and MACH alpha 1) is a 28 kDa member of the peptidase C14A family of enzymes. It is widely expressed and is considered an initiating caspase for the apoptotic cascade. Caspase-8 acts on a wide variety of substrates, including procaspases?3, 4, 6, 7, 9 and 10, c?FLIPL and procaspase-8 itself. Human procaspase?8a is a 54?56 kDa, 479 amino acid (aa) protein. It contains two N?terminal death domains (aa 1?177), followed by a catalytic site that utilizes His317Gly318 plus Cys360. Normally, it is an inactive, cytosolic monomer. But following death?domain (DD) containing receptor oligomerization, Caspase?8 is recruited to the death-inducing signaling complex (DISC) that forms around the death domains of the oligomerized receptor.
- 分子量
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Calculated MW: 17.27 kDa
Observed MW: 20 kDa
- UniProt
- O89110
- 途径
- Apoptosis, Caspase Cascade in Apoptosis, TLR signaling, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
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