MMP16 Protein (AA 151-450) (His tag)
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- 抗原 See all MMP16 蛋白
- MMP16 (Matrix Metallopeptidase 16 (Membrane-inserted) (MMP16))
- 蛋白类型
- Recombinant
- 产品特性
- AA 151-450
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This MMP16 protein is labelled with His tag.
- 序列
- Ala 151-Lys 450
- 产品特性
- A DNA sequence encoding the Human MMP16 protein (P51512) (Ala 151-Lys 450) was expressed with a N-His&C-His.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product MMP16 蛋白
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Matrix Metallopeptidase 16 (Membrane-inserted) (MMP16) (AA 120-607) protein (rho-1D4 tag)
Crystallography grade MMP16 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- MMP16 (Matrix Metallopeptidase 16 (Membrane-inserted) (MMP16))
- 别名
- MMP16 (MMP16 产品)
- 别名
- MT3-MMP Protein, Mt3mmp Protein, Mt3-mmp Protein, C8orf57 Protein, MMP-X2 Protein, MT-MMP2 Protein, MT-MMP3 Protein, matrix metallopeptidase 16 Protein, Mmp16 Protein, MMP16 Protein
- 背景
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Abbreviation: MMP16
Target Synonym: Matrix metalloproteinase-16,MMP16,
Background: Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix (ECM). MMP-16 (MT3-MMP) is found in brain, lung, placenta, smooth muscle cells, and malignant tumor tissues including oral melanoma and renal carcinoma . MMP-16 has been shown to activate proMMP-2 and degrade various ECM components including native collagens. MMP-16 has been proposed to possess the potential to directly enhance the growth and invasiveness of cells in vivo, two critical processes for development and carcinogenesis . Structurally, MMP-16 consists of the following domains: a pro domain containing the furin cleavage site, a catalytic domain containing the zinc-binding site, a hinge region, a hemopexin-like domain, a transmembrane domain, and a cytoplamasic tail . The structure of the catalytic domain in complex with a hydroxamate inhibitor has been solved . The rhMMP-16PC consists of the pro and catalytic domains, which can be activated by treatment with furin.
- 分子量
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Calculated MW: 32.89 kDa
Observed MW: 35 kDa
- UniProt
- P51512
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