Leptin Receptor Protein (LEPR) (AA 22-333) (His tag)
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- 抗原 See all Leptin Receptor (LEPR) 蛋白
- Leptin Receptor (LEPR)
- 蛋白类型
- Recombinant
- 产品特性
- AA 22-333
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This Leptin Receptor protein is labelled with His tag.
- 序列
- Phe 22-Val 333
- 产品特性
- A DNA sequence encoding the Human Ob-R protein (P48357) (Phe 22-Val 333) was expressed with a N-His tag.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product LEPR 蛋白
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Leptin Receptor (LEPR) (AA 22-839) protein (His tag)
LEPR 宿主: 人 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Leptin Receptor (LEPR) protein (Fc Tag)LEPR 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Leptin Receptor (LEPR) (AA 22-839) protein (His tag)LEPR 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Leptin Receptor (LEPR) protein (Fc Tag)LEPR 宿主: 小鼠 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Leptin Receptor (LEPR) (AA 31-130) protein (GST tag)LEPR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Leptin Receptor (LEPR) protein (mFc Tag)LEPR 宿主: 小鼠 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Leptin Receptor (LEPR) protein (His tag)LEPR 宿主: 小鼠 宿主: 人细胞 Recombinant >90 % as determined by reducing SDS-PAGE.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- Leptin Receptor (LEPR)
- 别名
- LEPR (LEPR 产品)
- 别名
- CD295 Protein, LEP-R Protein, LEPRD Protein, OB-R Protein, OBR Protein, obr Protein, cd295 Protein, ob-rb Protein, Fa Protein, LEPROT Protein, Leprb Protein, Modb1 Protein, OB-RGRP Protein, Obr Protein, db Protein, diabetes Protein, obese-like Protein, obl Protein, ObRb Protein, Ob-R Protein, Ob-RM Protein, lepr Protein, leptin receptor Protein, leptin receptor S homeolog Protein, LEPR Protein, lepr Protein, Lepr Protein, lepr.S Protein
- 背景
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Abbreviation: LEPR,CD295
Target Synonym: Leptin receptor,LEP-R,HuB219,OB receptor,OB-R,CD295,LEPR,DB,OBR
Background: Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Leptin Receptor/CD295 is a transmembrane catalytic receptors found on NPY/AgRP and alpha-MSH/CART neurons in hypothalamic nuclei. Leptin receptors (Ob-Rs) are coded for by one human gene that produces six different isoforms, Ob-Ra - Ob-Rf. Ob-Rs exist as constitutive dimers at physiological expression levels. Only the Ob-Rb isoform can transduce intracellular signals and does so through activation of the JAK2/STAT3, PI 3-K and MAPK signaling cascades. Activation of Ob-Rs mediates transcriptional regulation of the hypothalamic melanocortin pathway and downregulates endocannabinoid expression. Leptin acts via leptin receptors. Leptin resistance has been proposed as a pathophysiological mechanism of obesity. In obese individuals, Ob-Ra (which is involved in active transport of leptin across the blood-brain barrier) expression is downregulated and the individual may be unresponsive to leptin signals. Ob-R antagonists are of great interest in the development of pharmacological treatments for obesity. Mutations in Leptin Receptor/CD295 have been associated with obesity and pituitary dysfunction.
- 分子量
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Calculated MW: 34.21 kDa
Observed MW: 35 kDa
- UniProt
- P48357
- 途径
- JAK/STAT Signaling, AMPK Signaling, Feeding Behaviour
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